D. Underhill

Publications164
h-index52
Citations24,925
Highly Influential Citations1,215
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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
Toll-like receptors (TLRs) have been shown to participate in the recognition of pathogens by the innate immune system, but it is not clear how a restricted family of receptors has the capacity to… Expand
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Mechanisms of phagocytosis in macrophages.
Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self,… Expand
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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, but not on the host. Toll-like receptors (TLRs) recognize PAMPs and mediate… Expand
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of interleukin-1β (IL-1β). NLRP3 secondary… Expand
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Phagocytosis of microbes: complexity in action.
The phagocytic response of innate immune cells such as macrophages is defined by the activation of complex signaling networks that are stimulated by microbial contact. Many individual proteins have… Expand
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Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Toll-like receptors (TLRs) mediate recognition of a wide range of microbial products including lipopolysaccharides, lipoproteins, flagellin, and bacterial DNA, and signaling through TLRs leads to the… Expand
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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
Macrophages orchestrate innate immunity by phagocytosing pathogens and coordinating inflammatory responses. Effective defence requires the host to discriminate between different pathogens. The… Expand
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Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
The Mycobiome In the past few years, much attention has been given to the trillions of bacterial inhabitants in our guts and the myriad of ways in which they influence our overall health. But what… Expand
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Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
Dectin-1 is a lectin receptor for beta-glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory… Expand
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Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin1
Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic… Expand
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