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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
- A. Ozinsky, D. Underhill, +5 authors A. Aderem
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 5 December 2000
Toll-like receptors (TLRs) have been shown to participate in the recognition of pathogens by the innate immune system, but it is not clear how a restricted family of receptors has the capacity to… Expand
Mechanisms of phagocytosis in macrophages.
Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self,… Expand
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, but not on the host. Toll-like receptors (TLRs) recognize PAMPs and mediate… Expand
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of interleukin-1β (IL-1β). NLRP3 secondary… Expand
Phagocytosis of microbes: complexity in action.
The phagocytic response of innate immune cells such as macrophages is defined by the activation of complex signaling networks that are stimulated by microbial contact. Many individual proteins have… Expand
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
- Benjamin N. Gantner, R. Simmons, Scott J. Canavera, S. Akira, D. Underhill
- Medicine, Biology
- The Journal of experimental medicine
- 5 May 2003
Toll-like receptors (TLRs) mediate recognition of a wide range of microbial products including lipopolysaccharides, lipoproteins, flagellin, and bacterial DNA, and signaling through TLRs leads to the… Expand
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
Macrophages orchestrate innate immunity by phagocytosing pathogens and coordinating inflammatory responses. Effective defence requires the host to discriminate between different pathogens. The… Expand
Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
The Mycobiome In the past few years, much attention has been given to the trillions of bacterial inhabitants in our guts and the myriad of ways in which they influence our overall health. But what… Expand
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
Dectin-1 is a lectin receptor for beta-glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory… Expand
Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin1
- A. Hajjar, D. O'Mahony, +4 authors C. Wilson
- Biology, Medicine
- The Journal of Immunology
- 1 January 2001
Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic… Expand