• Publications
  • Influence
Rotenone, Paraquat, and Parkinson’s Disease
Background Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson’s disease (PD). Certain pesticides mayExpand
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  • Open Access
Head injury and amyotrophic lateral sclerosis.
Recent data showed that soccer players in Italy had an unusually high risk of amyotrophic lateral sclerosis (ALS) and that repeated head trauma might have contributed to this increase. The authorsExpand
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  • Open Access
Designing and analysing case-control studies to exploit independence of genotype and exposure.
Genetic susceptibility and environmental exposures play a synergistic role in the aetiology of many diseases. We consider a case-control study of a rare disease in relation to a categorical exposureExpand
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Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis
  • G. Cooper, D. Umbach
  • Medicine, Biology
  • Journal of bone and mineral research : the…
  • 1 December 1996
Vitamin D receptor (VDR) polymorphisms have been strongly associated with bone mineral density (BMD) in some studies but not in others. We used a meta‐analytic approach to assess quantitatively theExpand
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XPD polymorphisms: effects on DNA repair proficiency.
XPD codes for a DNA helicase involved in transcription and nucleotide excision repair. Rare XPD mutations diminish nucleotide excision repair resulting in hypersensitivity to UV light and increasedExpand
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Prevalence of medication treatment for attention deficit-hyperactivity disorder among elementary school children in Johnston County, North Carolina.
OBJECTIVES This study estimated the prevalence of medication treatment for attention deficit-hyperactivity disorder (ADHD) among elementary school children in a North Carolina county. METHODSExpand
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  • Open Access
The use of case-parent triads to study joint effects of genotype and exposure.
Most noninfectious disease is caused by low-penetrance alleles interacting with other genes and environmental factors. Consider the simple setting where a diallelic autosomal candidate gene and aExpand
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Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.
RATIONALE Risk factors for asthma among farm women are understudied. OBJECTIVES We evaluated pesticide and other occupational exposures as risk factors for adult-onset asthma. METHODS StudyingExpand
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  • Open Access
DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk.
Bladder cancer is the sixth most common cancer in the United States. The main identified risk factor is cigarette smoking, which is estimated to contribute to up to 50% of new cases in men and 20% inExpand
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Gene Selection and Clustering for Time-course and Dose-response Microarray Experiments Using Order-restricted Inference
tl;dr
We propose an algorithm for selecting and clustering genes according to their time-course or dose-response profiles using gene expression data. Expand
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