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Rotenone, Paraquat, and Parkinson’s Disease
- C. Tanner, F. Kamel, +17 authors J. Langston
- Biology, Medicine
- Environmental health perspectives
- 26 January 2011
Background Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson’s disease (PD). Certain pesticides may… Expand
Head injury and amyotrophic lateral sclerosis.
- H. Chen, M. Richard, D. Sandler, D. Umbach, F. Kamel
- American journal of epidemiology
- 1 October 2007
Recent data showed that soccer players in Italy had an unusually high risk of amyotrophic lateral sclerosis (ALS) and that repeated head trauma might have contributed to this increase. The authors… Expand
Designing and analysing case-control studies to exploit independence of genotype and exposure.
Genetic susceptibility and environmental exposures play a synergistic role in the aetiology of many diseases. We consider a case-control study of a rare disease in relation to a categorical exposure… Expand
Are vitamin D receptor polymorphisms associated with bone mineral density? A meta‐analysis
Vitamin D receptor (VDR) polymorphisms have been strongly associated with bone mineral density (BMD) in some studies but not in others. We used a meta‐analytic approach to assess quantitatively the… Expand
XPD polymorphisms: effects on DNA repair proficiency.
XPD codes for a DNA helicase involved in transcription and nucleotide excision repair. Rare XPD mutations diminish nucleotide excision repair resulting in hypersensitivity to UV light and increased… Expand
Prevalence of medication treatment for attention deficit-hyperactivity disorder among elementary school children in Johnston County, North Carolina.
- A. Rowland, D. Umbach, L. Stallone, A. J. Naftel, E. Bohlig, D. Sandler
- American journal of public health
OBJECTIVES This study estimated the prevalence of medication treatment for attention deficit-hyperactivity disorder (ADHD) among elementary school children in a North Carolina county. METHODS… Expand
The use of case-parent triads to study joint effects of genotype and exposure.
Most noninfectious disease is caused by low-penetrance alleles interacting with other genes and environmental factors. Consider the simple setting where a diallelic autosomal candidate gene and a… Expand
Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.
- J. Hoppin, D. Umbach, +4 authors D. Sandler
- American journal of respiratory and critical care…
RATIONALE Risk factors for asthma among farm women are understudied. OBJECTIVES We evaluated pesticide and other occupational exposures as risk factors for adult-onset asthma. METHODS Studying… Expand
DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk.
- M. Stern, D. Umbach, C. V. van Gils, R. Lunn, J. Taylor
- Cancer epidemiology, biomarkers & prevention : a…
- 1 February 2001
Bladder cancer is the sixth most common cancer in the United States. The main identified risk factor is cigarette smoking, which is estimated to contribute to up to 50% of new cases in men and 20% in… Expand
Gene Selection and Clustering for Time-course and Dose-response Microarray Experiments Using Order-restricted Inference
- S. Peddada, E. Lobenhofer, L. Li, C. Afshari, C. Weinberg, D. Umbach
- Computer Science, Medicine
- 1 May 2003
We propose an algorithm for selecting and clustering genes according to their time-course or dose-response profiles using gene expression data. Expand