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Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease
TLDR
This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open‐label trial using intraputamenal (Ipu) infusion of recombinant human GDNF (liatermin). Expand
Computer simulations of morphologically reconstructed CA3 hippocampal neurons.
TLDR
The simulation results suggest that CA3 pyramidal cell bursting behavior does not require any special distribution of Ca(2+)-dependent channels and mechanisms and is sufficient to change the firing mode of CA3 neurons from bursting to nonbursting. Expand
An on-line archive of reconstructed hippocampal neurons
TLDR
An on-line archive of neuronal geometry to encourage the use of realistic dendritic structures in morphometry and for neuronal modeling and to facilitate the quantitative use of full three-dimensional reconstructions of neurons from the hippocampus and other brain regions is developed. Expand
Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity.
TLDR
It is shown that clinically useful DBS alleviates motor symptoms by regularizing basal ganglia activity and thereby improving thalamic relay fidelity, and demonstrates that high-frequency stimulation alone is insufficient to alleviate motor symptoms: DBS must be highly regular. Expand
Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration
TLDR
The use of classic imaging techniques, such as rhodamine-123, the highly advanced semi-conductor nanoparticles (quantum dots), and wide field microscopy as well as high-resolution multiphoton imaging are highlighted to study mitochondrial function in brain tissue. Expand
Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: Intracellular staining in vivo and in vitro
TLDR
Essential aspects of morphometric appearance and complex dendritic integration critical to CA1 pyramidal cell functioning are preserved across neurons defined from the two different hippocampal preparations used in this study. Expand
Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically.
TLDR
Comparing initiation and spread of normoxic spreading depression and the effects of putative gap junction blocking agents suggests that, although gap junctions may be essential for the spread ofnormoxic SD, they may play a less important role in theSpread of HSD. Expand
Mitochondrial and intrinsic optical signals imaged during hypoxia and spreading depression in rat hippocampal slices.
TLDR
The results show two mitochondrial responses to hypoxia: an initial depolarization that appears to be caused by depressed electron transport due to lack of oxygen and a later, sudden, sharpdepolarization linked to HSD. Expand
Dendrites of classes of hippocampal neurons differ in structural complexity and branching patterns
TLDR
Dendrites of reconstructed hippocampal neurons were analyzed for morphometric, topologic, and fractal parameters to investigate neuronal groupings and growth characteristics with a common set of assumptions and Hippocampal cell groupings were significantly differentiated by most parameters. Expand
Interneurons of the Dentate–Hilus Border of the Rat Dentate Gyrus: Morphological and Electrophysiological Heterogeneity
TLDR
It is proposed that the variability in repetitive firing behavior and morphology exhibited by each of these interneurons makes each interneuron unique and may provide a high level of fine tuning of inhibitory control critical to information processing in the dentate. Expand
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