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Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
TLDR
The relative activities and the major substrates of human steroid-metabolizing UGT2B enzymes, which are expressed in a wide variety of steroid target tissues, are clearly demonstrated. Expand
3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).
TLDR
The glucuronidation of AZT by UGT2B7, which is a UGT 2B protein expressed in the liver, is consistent with previous findings and supports the physiological relevance of this enzyme in AZT conjugation. Expand
Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics.
TLDR
The characterization of UGT2B17 as a xenobiotics-conjugating enzyme demonstrates that its role is not limited to androgen metabolism and that its specificity for exogenous substrates is different from other UGT 2B isoforms. Expand
Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial
TLDR
Recurrent adenomatous polyps can be markedly reduced by a combination of low oral doses of DFMO and sulindac and with few side effects. Expand
Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase.
TLDR
The expression of UGT2B28 type I in the breast and liver suggests a role of this enzyme in the androgen and estrogen metabolism in these tissues. Expand
Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases Published, JLR Papers in Press, March 16, 2003. DOI 10.1194/jlr.M300010-JLR200
TLDR
Data showed that several members of UGT1A and UGT2B families are capable of converting LA and AA metabolites into glucuronide derivatives, which is considered an irreversible step to inactivation and elimination of endogenous substances from the body. Expand
Six Rapid Tests for Direct Detection of Clostridium difficile and Its Toxins in Fecal Samples Compared with the Fibroblast Cytotoxicity Assay
TLDR
Six commercially available immunoassays for C. difficile detection with CBA produce reasonable predictive values, especially when both antigen and toxin are detected, and offer significant advantages over CBA in terms of turnaround time and ease of use. Expand
Accelerated Communication 3 *-AZIDO-3 *-DEOXYTHIMIDINE ( AZT ) IS GLUCURONIDATED BY HUMAN UDP-GLUCURONOSYLTRANSFERASE 2 B 7 ( UGT 2 B 7 )
3*-Azido-3*-deoxythymidine (AZT) is frequently prescribed to patients infected with the human immunodeficiency virus. After absorption, AZT is rapidly metabolized intoExpand
Pseudomembranous Colitis Caused by a Toxin A− B+ Strain of Clostridium difficile
TLDR
A case of severe pseudomembranous colitis due to a toxin A− B+ strain of Clostridium difficile in an immunosuppressed patient is reported and the implications for diagnostic testing in suspected C. Difficile-associated diarrhea are discussed. Expand
Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells.
TLDR
A differential regulation of different isoforms of steroid conjugating UGTs present in human prostate LNCaP cells is demonstrated, indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Expand
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