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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
In response to tissue stiffening, fibroblasts increase production of extracellular matrix while decreasing production of matrix-degrading enzymes and the fibrosis inhibitor prostaglandin E2.
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Universal physical responses to stretch in the living cell
With every beat of the heart, inflation of the lung or peristalsis of the gut, cell types of diverse function are subjected to substantial stretch. Stretch is a potent stimulus for growth,Expand
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Cellular senescence mediates fibrotic pulmonary disease
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lungExpand
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Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlyingExpand
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Unjamming and cell shape in the asthmatic airway epithelium.
From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems-both inert and living-have the potential to jam. The collective canExpand
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Mechanotransduction through growth-factor shedding into the extracellular space
Physical forces elicit biochemical signalling in a diverse array of cells, tissues and organisms, helping to govern fundamental biological processes. Several hypotheses have been advanced that linkExpand
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Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype
Background The mechanical properties of the extracellular matrix have an important role in cell growth and differentiation. However, it is unclear as to what extent cancer cells respond to changes inExpand
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Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro.
Deformation of the alveolar epithelial basement membrane with lung inflation has been implicated in blood-gas barrier breakdown during the development of ventilator-induced lung injury. To determineExpand
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Cell Elasticity Determines Macrophage Function
Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understoodExpand
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A Multiwell Platform for Studying Stiffness-Dependent Cell Biology
Adherent cells are typically cultured on rigid substrates that are orders of magnitude stiffer than their tissue of origin. Here, we describe a method to rapidly fabricate 96 and 384 well platformsExpand
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