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CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
These findings demonstrate a CD40-dependent mechanism for targeting tumor stroma in the treatment of cancer and demonstrate that cancer immune surveillance does not necessarily depend on therapy-induced T cells; rather, it is shown that tumor regression required macrophages but not T cells or gemcitabine. Expand
Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
Findings support the development of mRNA CAR-based strategies for carcinoma and other solid tumors by showing the potential of using mRNA-engineered T cells to evaluate, in a controlled manner, potential off-tumor on-target toxicities and showing that short-lived CAR T cells can induce epitope spreading and mediate antitumor activity in patients with advanced cancer. Expand
A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma
CP-870,893 in combination with gemcitabine was well-tolerated and associated with antitumor activity in patients with PDA, and changes in FDG uptake detected on PET/CT imaging provide insight into therapeutic benefit. Expand
Structural and functional imaging of normal bone marrow and evaluation of its age-related changes.
A review of MRI and scintigraphy of normal bone marrow with some emphasis on FDG-PET imaging in assessing marrow activity in normal and abnormal states is presented and preliminary data regarding normal age-related changes in bone marrow through use of FDg-PET is presented. Expand
Diagnostic Performance of FDG-PET, MRI, and Plain Film Radiography (PFR) for the Diagnosis of Osteomyelitis in the Diabetic Foot
FDG-PET is a highly specific imaging modality for the diagnosis of osteomyelitis in diabetic foot and should be considered to be a useful complimentary Imaging modality with MRI in the setting where MRI is contraindicated. Expand
Positron emission tomography as a diagnostic tool in infection: present role and future possibilities.
The ability of FDG-PET to diagnose vascular graft infection and fistula, even when the anatomical imaging modalities are inconclusive, is of considerable interest to practitioners of vascular surgery and this combined modality approach may prove to be the study of choice in foreseeable future for precise localization of involved sites. Expand
Retained Surgical Foreign Bodies: A Comprehensive Review of Risks and Preventive Strategies
The authors discuss the available evidence with regards to risk factors associated with RSFB as well as methods of minimizing the incidence and the relationship between RSFB and surgical training with emphasis on education in early recognition, prevention, and focus on teamoriented training strategies. Expand
Impacts of Salmon on Riparian Plant Diversity
The study of natural gradients in nutrient subsidies between ecosystems allows for predictions of how changes in one system can affect biodiversity in another. We performed a large-scale empiricalExpand
Functional imaging of inflammatory diseases using nuclear medicine techniques.
Functional imaging, led by FDG-PET imaging, is likely to play an increasingly critical role in assessing inflammatory disorders of known and unknown etiologies, and will improve their management immensely in the future. Expand
Tongue fat and its relationship to obstructive sleep apnea.
There is increased tongue volume and deposition of fat at the base of tongue in apneics compared to controls, and increased tongue fat may begin to explain the relationship between obesity and obstructive sleep apnea. Expand