• Publications
  • Influence
Melanin pigmentation in mammalian skin and its hormonal regulation.
Melanogenesis is a highly structured system, active since early embryogenesis and capable of superselective functional regulation that may reach down to the cellular level represented by single melanocytes, and its significance extends beyond the mere assignment of a color trait. Expand
Hair follicle pigmentation.
Follicular melanogenesis involves sequentially the melanogenic activity of follicular melanocytes, the transfer of melanin granules into cortical and medulla keratinocytes, and the formation of pigmented hair shafts, which is stringently coupled to the anagen stage of the hair cycle. Expand
Functional activity of serotoninergic and melatoninergic systems expressed in the skin
Skin cells represent a true target for the products of the serotoninergic/melatoninergic cutaneous pathway with their actions modulating cell proliferation or viability, according to cell type and culture conditions. Expand
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun
The widespread expression of a cutaneous seorotoninergic/melatoninergic system indicates considerable selectivity of action to facilitate intra‐, auto‐, or paracrine mechanisms that define and influence skin function in a highly compartmentalized manner. Expand
Modelling the buried human body environment in upland climes using three contrasting field sites.
The results of these studies demonstrated that soil conditions at these three burial sites has a marked effect on the condition of the buried body but even within a single site variation can occur; the process of soft tissue decomposition modifies the localised burial microenvironment in terms of microbiological load, pH, moisture and changes in redox status. Expand
Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control.
The hair follicle mesenchyme exhibits significant hair cycle-associated plasticity, and modulation of these cell interchanges is likely to be important during clinically importanthair follicle transformations, e.g. vellus-to-terminal and terminal- to-vellus during androgenetic alopecia. Expand
Graying: gerontobiology of the hair follicle pigmentary unit
One of the surprising results of pigment loss in canities is the alteration in keratinocyte proliferation and differentiation, providing the tantalizing suggestion that melanocytes in the hair follicle contribute far more that packages of melanin alone. Expand
Introduction to skin aging.
  • D. Tobin
  • Medicine
  • Journal of tissue viability
  • 1 February 2017
The topic of human skin aging is introduced, with a focus on how maintenance of function in this complex multi-cell type organ is key for retaining quality of life into old age. Expand
Melatonin in the skin: synthesis, metabolism and functions
The properties of endogenous melatonin suggest that this molecule is an important effector of stress responses in the skin, and actions may counteract or buffer both environmental and endogenous stressors to maintain skin integrity. Expand
Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB.
The results identify a mechanism in which stress signalling via p38 leads to activation of CREB, enhanced Mitf expression and consequently increased tyrosinase expression, which is relevant for the regulation of melanocytes by Mitf, but also raises the possibility that lipid mediated activation of p38 signalling may represent a potential therapy for vitiligo. Expand