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Is there a common water-activity limit for the three domains of life?
Archaea and Bacteria constitute a majority of life systems on Earth but have long been considered inferior to Eukarya in terms of solute tolerance. Whereas the most halophilic prokaryotes are knownExpand
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The 67 kDa laminin receptor: structure, function and role in disease.
The 67LR (67 kDa laminin receptor) is a cell-surface receptor with high affinity for its primary ligand. Its role as a laminin receptor makes it an important molecule both in cell adhesion to theExpand
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Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life.
Since a key requirement of known life forms is available water (water activity; aw ), recent searches for signatures of past life in terrestrial and extraterrestrial environments have targeted placesExpand
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DNA ligases in the repair and replication of DNA.
DNA ligases are critical enzymes of DNA metabolism. The reaction they catalyse (the joining of nicked DNA) is required in DNA replication and in DNA repair pathways that require the re-synthesis ofExpand
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Fine tuning the myosin motor: the role of the essential light chain in striated muscle myosin.
  • D. Timson
  • Medicine, Biology
  • Biochimie
  • 1 July 2003
It has long been known that the essential light chain isoform of striated muscle affects the function of the myosin motor. There are two isoforms: A1-type and A2-type that differ by the presence ofExpand
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The biology of habitat dominance; can microbes behave as weeds?
Competition between microbial species is a product of, yet can lead to a reduction in, the microbial diversity of specific habitats. Microbial habitats can resemble ecological battlefields whereExpand
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Functional domains of an NAD+-dependent DNA ligase.
Limited proteolysis of the NAD+-dependent DNA ligase from Bacillus stearothermophilus with thermolysin results in two fragments which were resistant to further proteolysis. These fragments wereExpand
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A universal measure of chaotropicity and kosmotropicity.
Diverse parameters, including chaotropicity, can limit the function of cellular systems and thereby determine the extent of Earth's biosphere. Whereas parameters such as temperature, hydrophobicity,Expand
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The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function.
There are two isoforms (A1 and A2) of the myosin essential light chain (ELC) and consequently two isoenzymes of myosin subfragment 1 (S1), S1(A1) and S1(A2). The two isoenzymes differ in theirExpand
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Structure of the adenylation domain of an NAD+-dependent DNA ligase.
BACKGROUND DNA ligases catalyse phosphodiester bond formation between adjacent bases in nicked DNA, thereby sealing the nick. A key step in the catalytic mechanism is the formation of an adenylatedExpand
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