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Bioenergetics of intact human muscle. A 31P nuclear magnetic resonance study.
The dynamics of metabolic changes can now be observed with a time resolution of 10 to 60 seconds and thus disturbances in energy metabolism can be readily detected in several pathological states.
Energetics of human muscle: Exercise‐induced ATP depletion
Loss of ATP was associated with altered recovery of the muscle: phosphocreatine, Pi, and pH returned more slowly to their pre‐exercise values and the initial rate of oxidative phosphorylation was diminished.
Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia.
The results show that FRDA is a nuclear-encoded mitochondrial disorder affecting oxidative phosphorylation and give a rationale for treatments aimed to improve mitochondrial function in this condition.
Mechanics of airflow in the human nasal airways
The mechanics of airflow in the human nasal airways is reviewed, drawing on the findings of experimental and computational model studies, and some of the improved capabilities afforded by technological developments for future model studies are illustrated.
Ageing: Effects on oxidative function of skeletal muscle in vivo
In the adults, the intracellular pH change during exercise diminished with increasing age, resulting in higher calculated free [ADP] and possibly serving as an adaptive mechanism to stimulate mitochondrial ATP production.
Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.
It is concluded that p38 MAPK plays an important role in the regulation of some, but not all, responses to IL-1, and it is involved in theregulation of mRNA levels of someIL-1-responsive genes.
Quantitative analysis by 31P magnetic resonance spectroscopy of abnormal mitochondrial oxidation in skeletal muscle during recovery from exercise
We use the hyperbolic relationship between cytosolic [ADP] and the rate of phosphocreatine (PCr) resynthesis after exercise to estimate the apparent maximum rate of oxidative ATP synthesis (QMAX). We
Investigation of human mitochondrial myopathies by phosphorus magnetic resonance spectroscopy
Monitoring the metabolism of high‐energy phosphates and the intracellular pH of human skeletal muscle in vivo in 12 patients with mitochondrial myopathy found phosphorus magnetic resonance spectroscopy is useful in the noninvasive diagnosis of mitochondrial myopathies and in defining the pathophysiological basis of these disorders.
Increased concentration of pro-matrix metalloproteinase 9 in term fetal membranes overlying the cervix before labor: implications for membrane remodeling and rupture.
This study suggests that a specific regional induction of pro-matrix metalloproteinase 9 occurs in the cervical area before labor and may play a role in "programming" this area for subsequent rupture after activation during labor.
Cellular energetics of dystrophic muscle
Raised intracellular pH thus appears to be the most characteristic abnormality in dystrophin-deficient muscle, and recovery of PCr, Pi and ADP after exercise were not impaired, suggesting that mitochondrial function is normal.