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Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential
WT1126 (RMFPNAPYL) is a human leukocyte antigen-A2 (HLA-A2)-restricted peptide derived from Wilms tumor protein 1 (WT1), which is widely expressed in a broad spectrum of leukemias, lymphomas andExpand
Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo
Murine IgG3 anti-GD2 antibody m3F8 has shown anti-neuroblastoma activity in Phase I/II studies, where antibody-dependent cell-mediated cytotoxicity (ADCC) played a key role. Humanization of m3F8Expand
Retargeting NK92 cells using an HLA-A2-restricted, EBNA3C-specific chimeric antigen receptor
Advances in adoptive cell immunotherapy have led to several promising options for cancer patients. Single-chain variable fragments (scFvs) were isolated from a human phage display library by panningExpand
Monoclonal antibody therapies for solid tumors.
BACKGROUND About 1.4 million new cancer cases are expected to be diagnosed in the US in 2008 and the overall costs of cancer treatment is estimated at > $200 billion per year. Over half a millionExpand
Monoclonal antibody therapies for solid tumors
Background: About 1.4 million new cancer cases are expected to be diagnosed in the US in 2008 and the overall costs of cancer treatment is estimated at > $200 billion per year. Over half a millionExpand
Antimicrobial Susceptibility Testing of Novel Anticancer Derivatives against Infectious Bacteria for the Potential Minimization of Nosocomial Infections
4 Chapter 1 : Introduction 5-8 Chapter 2: Materials and Methods 9-12 a. Bacterial Isolates 9 b. Anticancer Derivatives 9 c. MIC Determination 9-11 Chapter 3: Results 13-18 Chapter 4: Discussion 19-24Expand