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Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential
TLDR
T-cell epitopes can provide novel targets for antibody-based therapeutics and by combining phage and yeast displays and scFv-Fc fusion platforms, a strategy for developing high-affinity TCR-like antibodies could be rapidly explored for potential clinical development.
Retargeting NK92 cells using an HLA-A2-restricted, EBNA3C-specific chimeric antigen receptor
TLDR
For the first time, the successful reprogramming of non-T cells toward a specific TCE using a CAR is shown, with detection sensitivity of approximately 25 molecules and cytolytic capacity threefold greater than scFv-Fc-mediated ADCC.
Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo
TLDR
Humanization of m3F8 produced next generation anti-GD2 antibodies with substantially more potent ADCC in vitro and anti-tumor activity in vivo, which may be clinically more effective, while minimizing pain and HAMA side effects.
Monoclonal antibody therapies for solid tumors.
TLDR
Clinical efficacy of FDA-approved and investigational monoclonal antibody therapies are summarized and the advent of novel antibody engineering and combination therapy strategies has generated much optimism for current and future antibody-based therapeutics in solid tumors.
Monoclonal antibody therapies for solid tumors
TLDR
Anti-tumor responses have been modest and the advent of novel antibody engineering and combination therapy strategies has generated much optimism for current and future antibody-based therapeutics in solid tumors.
Antimicrobial Susceptibility Testing of Novel Anticancer Derivatives against Infectious Bacteria for the Potential Minimization of Nosocomial Infections
TLDR
This research presents a novel and scalable approach called “Smart MIC Determination” that allows for real-time, scalable and efficient analysis of the MIC determinants of Bacterial Isolates.