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A 4-year trial of tiotropium in chronic obstructive pulmonary disease.
TLDR
Therapy with tiotropium was associated with improvements in lung function, quality of life, and exacerbations during a 4-year period but did not significantly reduce the rate of decline in FEV(1). Expand
Cyclophosphamide versus placebo in scleroderma lung disease.
TLDR
One year of oral cyclophosphamide in patients with symptomatic scleroderma-related interstitial lung disease had a significant but modest beneficial effect on lung function, dyspnea, thickening of the skin, and the health-related quality of life. Expand
A placebo-controlled, randomized trial of mesenchymal stem cells in COPD.
TLDR
Systemic MSC administration appears to be safe in patients with moderate to severe COPD and provides a basis for subsequent cell therapy investigations. Expand
Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
TLDR
Tiotropium seemed to reduce the rate of decline of postbronchodilator FEV(1) in patients with GOLD stage II COPD, suggesting that treatment of COPD should begin at an early stage of the disease. Expand
Effects of Smoking Intervention and the Use of an Inhaled Anticholinergic Bronchodilator on the Rate of Decline of FEV1: The Lung Health Study
TLDR
An aggressive smoking intervention program significantly reduces the age-related decline in FEV 1 in middle-aged smokers with mild airways obstruction and use of an inhaled anticholinergic bronchodilator results in a relatively small improvement inFEV 1 that appears to be reversed after the drug is discontinued. Expand
C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease
TLDR
CRP measurements provide incremental prognostic information beyond that achieved by traditional markers of prognosis in patients with mild to moderate COPD, and may enable more accurate detection of patients at a high risk of mortality. Expand
Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivors of non-small cell lung cancer.
TLDR
The majority of long-term survivors of non-small cell lung cancer experienced respiratory symptoms, and more than one third reported dyspnea, including one of five patients with seriously diminished pulmonary function. Expand
Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease
TLDR
The existing data for LAMA/LABA combinations in the treatment of COPD is outlined, the ongoing trials are summarized, and the evidence required to inform the role of LAMA-LABA combination in treatment of this disease is considered. Expand
Effects of varenicline on smoking cessation in patients with mild to moderate COPD: a randomized controlled trial.
TLDR
Varenicline was more efficacious than placebo for smoking cessation in patients with mild to moderate COPD and demonstrated a safety profile consistent with that observed in previous trials. Expand
Cannabis withdrawal among non-treatment-seeking adult cannabis users.
TLDR
Study findings provide evidence for the clinical significance of a cannabis withdrawal syndrome, based on the high prevalence and co-occurrence of multiple symptoms that follow a consistent time course and that prompt action by the subjects to obtain relief, including serving as negative reinforcement for cannabis use. Expand
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