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Long-term evaluation of deep brain stimulation of the thalamus.
Thalamic stimulation is safe and effective for the long-term management of essential and Parkinsonian tremors and Bilateral stimulation can cause dysarthria and incoordination and should be used cautiously.
High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor
Chronic high‐frequency stimulation of the ventral intermedius nucleus of the thalamus is safe and highly effective in ameliorating essential and parkinsonian tremor and measures of function were significantly improved in patients with essential tremor.
Novel THAP1 sequence variants in primary dystonia
A heterogeneous collection of THAP1 sequence variants is associated with varied anatomical distributions and onset ages of both familial and sporadic primary dystonia.
Botulinum toxin type B: A double-blind, placebo-controlled, safety and efficacy study in cervical dystonia
BotB is safe, well tolerated, and efficacious in the treatment of cervical dystonia at the doses tested and a statistically significant treatment effect and a dose response.
Cholinergic-adrenergic hypothesis of mania and depression.
Abnormalities of spatial and temporal sensory discrimination in writer's cramp
- Terence Sanger, D. Tarsy, Á. Pascual-Leone
- Psychology, MedicineMovement disorders : official journal of the…
- 1 January 2001
The fingertip discrimination of the orientation of fine spatial gratings between writer's cramp and control subjects is compared and a significant decrease in grating sensitivity in the patients is found, consistent with the possibility of enlarged tactile receptive fields.
Focal contralateral myoclonus produced by inhibition of GABA action in the caudate nucleus of rats.
Epidemiology of tardive dyskinesia: Is risk declining with modern antipsychotics?
Long‐term use of APDs should continue to be based on research‐supported indications, with regular specific examination for emerging TD, as available evidence suggests that the risk of TD may be declining, but longitudinal studies of patients never treated with traditional neuroleptics and exposed to only a single modern APD are required to quantify TD risks.
Effects of Newer Antipsychotics on Extrapyramidal Function
No atypical antipsychotic is clearly effective for motor abnormalities in Huntington’s disease or Tourette's syndrome, and the effect of these drugs on other neurological disorders have been well evaluated in only small numbers of patients.
Double‐blind, randomized, controlled trial of rasagiline as monotherapy in early Parkinson's disease patients
- M. Stern, K. Marek, +4 authors C. Olanow
- MedicineMovement disorders : official journal of the…
- 1 August 2004
The results suggest that rasagiline monotherapy is well tolerated and efficacious in early Parkinson's disease (PD) patients not receiving levodopa.