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A microarray for microRNA profiling in mouse testis tissues.
The data indicated specific miRNAAs expression in immature mouse testis and suggested that miRNAs have a role in regulating spermatogenesis, which is suggested by MiRscan performing miRNA target scanning.
Microarray profiling of microRNAs expressed in testis tissues of developing primates
PicTar and TargetScan prediction tools predicted a number of target mRNAs, and some of these target genes predicted by miRNAs have been shown to associate with spermatogenesis.
Piwil2 Suppresses P53 by Inducing Phosphorylation of Signal Transducer and Activator of Transcription 3 in Tumor Cells
Human piwil2, or Hili represses the tumor suppressor P53 in human cancer cells and plays a role in anti-apoptosis in tumor cells possessing P53 as a positive regulator of STAT3 signaling pathway, providing novel sights into roles of Piwil2 in tumorigenesis.
Zili Inhibits Transforming Growth Factor-β Signaling by Interacting with Smad4*
This work shows that zili plays a role in early embryogenesis beyond germ line as a novel negative regulator of TGF-β signaling, extending the function of Piwi proteins in vertebrates.
Evidence for the association of Y-chromosome haplogroups with susceptibility to spermatogenic failure in a Chinese Han population
Evidence is provided for the association of Y-chromosome background with impaired spermatogenesis, suggesting that Y variations play a role in the occurrence and even the severity of sperMatogenic failure.
Identification of piRNAs in Hela cells by massive parallel sequencing.
It is demonstrated that HILI along with piRNAs plays a role in LINE1 suppression in HeLa cancer cell line.
Y chromosome haplogroups may confer susceptibility to partial AZFc deletions and deletion effect on spermatogenesis impairment.
The findings indicate that some monophyletic Y chromosomes may be associated with predisposition to specific subtypes of partial AZFc deletion and adverse effect on spermatogenesis in a Chinese population.
Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population.
As a common variation in the azoospermia factor c (AZFc) region of Y chromosome, the gr/gr deletion is regarded as a significant risk factor for spermatogenic impairment, whereas the association of
PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation
It is shown that Piwi-Like RNA-Mediated Gene Silencing 2 (PIWIL2) can upregulate c-Myc via binding with NME/NM23 nucleoside diphosphate kinase 2 (NME2) and modulates tumor cell proliferation and F-actin filaments via promoting c- myc expression.