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One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?
TLDR
This review focuses on melatonin metabolism which includes the synthetic rate‐limiting enzymes, synthetic sites, potential regulatory mechanisms, bioavailability in humans, mechanisms of breakdown and functions of its metabolites. Expand
Melatonin and the ovary: physiological and pathophysiological implications.
TLDR
Melatonin could become an important medication for improving ovarian function and oocyte quality, and open new opportunities for the management of several ovarian diseases. Expand
Actions of melatonin in the reduction of oxidative stress. A review.
Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species,Expand
Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.
TLDR
Under in vivo conditions, melatonin is often several times more potent than vitamin C and E in protecting tissues from oxidative injury when compared at an equivalent dosage (micromol/kg). Expand
Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
TLDR
Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiencyof other antioxidants. Expand
Actions of Melatonin in the Reduction of Oxidative Stress
Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species,Expand
Melatonin as an antioxidant: under promises but over delivers
TLDR
It is the current feeling of the authors that, in view of the widely diverse beneficial functions that have been reported for melatonin, these may be merely epiphenomena of the more fundamental, yet‐to‐be identified basic action(s) of this ancient molecule. Expand
Melatonin as a natural ally against oxidative stress: a physicochemical examination
TLDR
This review summarizes the current progress in understanding the physicochemical insights related to the free radical–scavenging activity of melatonin and concludes that melatonin efficiently protects against oxidative stress by a variety of mechanisms. Expand
Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation.
TLDR
Observations suggest that melatonin, a ubiquitously distributed small nonenzymatic molecule, might serve to directly detoxify H( 2)O(2) in living organisms. Expand
Biochemical reactivity of melatonin with reactive oxygen and nitrogen species
TLDR
In vitro melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species; in vivo, it is an effective pharmacological agent in reducing oxidative damage under conditions in which excessive free radical generation is believed to be involved. Expand
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