• Publications
  • Influence
Driving pressure and survival in the acute respiratory distress syndrome.
BACKGROUND Mechanical-ventilation strategies that use lower end-inspiratory (plateau) airway pressures, lower tidal volumes (VT), and higher positive end-expiratory pressures (PEEPs) can improveExpand
  • 953
  • 63
  • PDF
Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis.
CONTEXT Trials comparing higher vs lower levels of positive end-expiratory pressure (PEEP) in adults with acute lung injury or acute respiratory distress syndrome (ARDS) have been underpowered toExpand
  • 1,003
  • 58
Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study.
RATIONALE Accurate, early identification of patients at risk for developing acute lung injury (ALI) provides the opportunity to test and implement secondary prevention strategies. OBJECTIVES ToExpand
  • 413
  • 28
  • PDF
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data
Background: Hyperglycemia is associated with increased mortality in critically ill patients. Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality andExpand
  • 969
  • 23
  • PDF
An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute
Background: This document provides evidence‐based clinical practice guidelines on the use of mechanical ventilation in adult patients with acute respiratory distress syndrome (ARDS). Methods: AExpand
  • 352
  • 19
Serum lactate as a predictor of mortality in emergency department patients with infection.
STUDY OBJECTIVE Little is known about risk-stratification biomarkers in emergency department (ED) patients with suspected infection, and lactate is a biologically plausible candidate. We determineExpand
  • 546
  • 16
Occult hypoperfusion and mortality in patients with suspected infection
ObjectiveTo determine, in the early stages of suspected clinically significant infection, the independent relationship of the presenting venous lactate level to 28-day in-hospitalExpand
  • 286
  • 14
  • PDF
Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol*
Objectives:To describe the effectiveness of a comprehensive, interdisciplinary sepsis treatment protocol with regard to both implementation and outcomes and to compare the mortality rates andExpand
  • 363
  • 13
Ketamine Attenuates the Interleukin-6 Response After Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) has been proposed as a model for studying the inflammatory cascade associated with the systemic inflammatory response syndrome.Serum interleukin-6 (IL-6) concentrationExpand
  • 128
  • 11
Proof of principle: The predisposition, infection, response, organ failure sepsis staging system*
Objective:In an effort to improve upon the traditional sepsis syndrome definitions, the predisposition, infection, response, organ dysfunction (PIRO) model was proposed to better characterize sepsis.Expand
  • 116
  • 10