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Antitrypanosomal and Antileishmanial Activities of Flavonoids and Their Analogues: In Vitro, In Vivo, Structure-Activity Relationship, and Quantitative Structure-Activity Relationship Studies
- D. Taşdemir, M. Kaiser, P. Rüedi
- Chemistry, BiologyAntimicrobial Agents and Chemotherapy
- 1 April 2006
A large set of flavonoid aglycones and glycosides were surveyed, as well as a panel of other related compounds of phenolic and phenylpropanoid nature, for their in vitro activities against Trypanosoma brucei rhodesiense, T. cruzi, and Leishmania donovani, and generally, the test compounds lacked cytotoxicity in vitro and in vivo.
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
- D. Taşdemir, Gabriela Lack, R. Brun, P. Rüedi, L. Scapozza, R. Perozzo
- Biology, ChemistryJournal of medicinal chemistry
- 2 May 2006
Polyphenols of C-3 gallic acid esters of catechins showed in vitro activity against chloroquine-sensitive and -resistant P. falciparum strains in the low to submicromolar range.
Dietary chalcones with chemopreventive and chemotherapeutic potential
- B. Orlíková, D. Taşdemir, F. Golais, M. Dicato, M. Diederich
- Biology, ChemistryGenes & Nutrition
- 4 February 2011
The inhibitory effects of these compounds on the different steps of carcinogenesis that reveal interesting chemopreventive and chemotherapeutic potential will be discussed.
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites
Results indicate longamide B and dibromopalau’amine (11) to be promising trypanocidal and antileishmanial agents, while dispacamide B (3) and spongiacidin B (6) emerge as antimalarial lead compounds.
Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.
- D. Taşdemir, G. C. Mangalindan, C. Ireland
- Chemistry, BiologyJournal of natural products
- 26 January 2002
Two new isomalabaricane triterpenes have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines and showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor cells.
Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.
- E. Regalado, D. Taşdemir, M. Kaiser, N. Cachet, P. Amade, O. Thomas
- ChemistryJournal of natural products
- 8 July 2010
The chemical composition of the Caribbean sponge Pandaros acanthifolium was reinvestigated and led to the isolation of 12 new steroidal glycosides, namely, pandarosides E-J and their methyl esters (7-12), which showed in vitro activity against three or four parasitic protozoa.
Inhibitory Activity of Marine Sponge-Derived Natural Products against Parasitic Protozoa
This is the first report of antiprotozoal activity of marine metabolites 1–14, and points out the potential of marine sponges in discovery of new antipro tozoal lead compounds.
Heart health peptides from macroalgae and their potential use in functional foods.
- C. Fitzgerald, E. Gallagher, D. Taşdemir, M. Hayes
- BiologyJournal of agricultural and food chemistry
- 6 June 2011
The purpose of this review is to highlight the potential of heart health peptides from macroalgae and to discuss the feasibility of expanding the variety of foods these peptides may be used in.