• Publications
  • Influence
Investigations on the synthesis and pharmacological properties of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones.
TLDR
All compounds tested significantly suppressed the spontaneous locomotor activity of mice and prolonged barbiturate sleep of these animals and all compounds studied exhibited potent analgesic activity which was superior than that of acetylsalicylic acid. Expand
Synthesis and properties of 2-(4-substituted)butyl derivatives of some 2,3-dihydro-1,3-dioxo-1H-pyrrolo[3,4-c]pyridines.
TLDR
All the compounds tested showed a strong analgesic action, suppressed spontaneous locomotor activity and prolonged barbiturate sleep, and all significantly decreased systolic and diastolic blood pressure. Expand
Synthesis, Cyclooxygenases Inhibition Activities and Interactions with BSA of N-substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones Derivatives
TLDR
A novel N-substituted 1H-pyrrolo[3–c]pyridine-1,3(2H)-diones derivatives were synthesized and biologically evaluated for their inhibitory activity against cyclooxygenases and interactions with BSA and confirmed the main interaction forces between studied compounds and BSA were hydrogen bonding and van der Waals force. Expand
Antinociceptive, antiedematous, and antiallodynic activity of 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione derivatives in experimental models of pain
TLDR
Both DSZ 1 and DSZ 3 displayed broad spectrum of activity in several pain models, including neurogenic, tonic, inflammatory, and chemotherapy-induced peripheral neuropathic pain. Expand
Bioresearch of New 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones
TLDR
All of the new imides inhibited the locomotor activity in mice to a statistically significant extent, and two of them also prolonged the duration of thiopental sleep. Expand
Investigations on the synthesis and pharmacological properties of 4-alkoxy-2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl]-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones.
TLDR
The compounds 8-12 exhibited potent analgesic activity which was superior than that of acetylsalicylic acid in two different tests and most of the investigated imides suppressed significantly spontaneous locomotor activity in mice. Expand
A validated spectrophotometric and liquid chromatography method for determination and purity evaluation of
TLDR
Kinetic studies of the decomposition process of I in both acidic and alkaline environments indicate instability of the imide group, as indicated by the results of spectrophotometric analysis. Expand
Forced Degradation and Photodegradation Studies of Pyrrolo[3,4-c]pyridine-1,3-dione Derivatives as Analgesic Active Compounds Using HPLC, UV and IR Spectrometry, and HPLC/MS Methods.
TLDR
Analysis of observed photodegradation products showed degradation targeted at the breaking of the pyrrolo[3,4-c]pyridine-1,3-dione, piperazine, and/or tetrahydroisoquinoline rings. Expand
Synthesis and properties of 4-alkoxy-2-[2-hydroxy-3-(4-o,m,p-halogenoaryl-1 -piperazinyl)propyl]-6-methyl-1H-pyrrolo-[3,4-c]pyridine-1,3(2H)-diones with analgesic and sedative activities.
TLDR
All final imides studied exhibited analgesic activity in the "writhing syndrome" test which was superior than that of acetylsalicylic acid and all compounds tested significantly suppressed the spontaneous locomotor activity of mice. Expand
...
1
2
...