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Apolipoprotein E inhibition of vascular smooth muscle cell proliferation but not the inhibition of migration is mediated through activation of inducible nitric oxide synthase.
Initial experiments revealed that low concentrations of apolipoprotein (apo) E (0.1 to 5 microg/mL) were effective in inhibiting platelet-derived growth factor (PDGF)-directed smooth muscle cellExpand
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  • Open Access
Apolipoprotein AIV: a potent endogenous inhibitor of lipid oxidation.
Overexpression of apolipoprotein (apo) AIV in transgenic mice confers significant protection against atherosclerosis in apoE knockout animals even in the presence of a more severe atherogenic lipidExpand
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Apolipoprotein E Receptor Binding VersusHeparan Sulfate Proteoglycan Binding in Its Regulation of Smooth Muscle Cell Migration and Proliferation*
This study showed that synthetic peptides containing either a single copy or tandem repeat of the receptor binding domain sequence of apolipoprotein (apo) E, or a peptide containing its C-terminalExpand
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Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury.
The function of apolipoprotein J (apoJ) is unknown, but it has been hypothesized to be cytoprotective. In the normal heart, abundant apoJ mRNA and protein are expressed in atrial myocytes; noExpand
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Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis.
Apolipoprotein J (apoJ), a glycoprotein associated with subclasses of plasma high density lipoproteins (HDL), was found to accumulate in aortic lesions in a human subject withExpand
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Low Density Lipoprotein Receptor-related Protein Mediates Apolipoprotein E Inhibition of Smooth Muscle Cell Migration*
This research was undertaken to identify the cell surface receptor responsible for mediating apolipoprotein E (apoE) inhibition of platelet-derived growth factor (PDGF)-directed smooth muscle cellExpand
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  • Open Access
Apolipoprotein E: a cholesterol transport protein with lipid transport-independent cell signaling properties.
  • D. Swertfeger, D. Hui
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual…
  • 1 March 2001
Apolipoprotein (apo) E is a 34-kDa glycoprotein associated with plasma lipoproteins. In contrast to other apolipoproteins, apoE is expressed ubiquitously in all tissues and appears to have a wideExpand
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  • 1
  • Open Access
Apolipoprotein J/clusterin expression defines distinct stages of blastocyst implantation in the mouse uterus.
The endometrium is a dynamic tissue that responds to hormonal cues and growth factors to accommodate, regulate, and nurture developing embryos. To provide clues about the molecular mechanismsExpand
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  • Open Access
Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase*
The anti-atherogenic effects of apolipoprotein (apo) E have been attributed to its ability to reduce plasma cholesterol level and to limit foam cell formation. The purpose of this study was toExpand
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Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation.
The current study compared the effectiveness of the various human apolipoprotein E (apoE) isoforms in inhibiting platelet-derived growth factor- (PDGF-) stimulated smooth muscle cell proliferationExpand
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