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Structural and metabolic requirements for activators of the peroxisome proliferator-activated receptor.
Fatty acids have recently been demonstrated to activate peroxisome proliferator-activated receptors (PPARs) but specific structural requirements of fatty acids to produce this response have not yetExpand
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Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production
IntroductionThe steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regardedExpand
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Mineralogical investigations of the first package of the alternative buffer material test – I. Alteration of bentonites
Abstract Bentonite, which is envisaged as a promising engineered barrier material for the safe disposal of highly radioactive waste, was and is investigated in different large scale tests. The mainExpand
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The Antimicrobial Peptide LL-37 Alters Human Osteoblast Ca2+ Handling and Induces Ca2+-Independent Apoptosis
The human antimicrobial peptide cathelicidin LL-37 has, besides its antimicrobial properties, also been shown to regulate apoptosis in a cell type-specific manner. Mechanisms involved inExpand
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1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human periodontal ligament cells.
BACKGROUND AND OBJECTIVE The aim of this study was to assess the impact of 1α,25-dihydroxyvitamin D3 (vitamin D3) on osteogenic and inflammatory properties of human periodontal ligament (PDL) cellsExpand
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Dextran Sulfate Sodium‐induced Colitis Generates a Transient Thymic Involution – Impact on Thymocyte Subsets
One of the most widely used animal models for inflammatory bowel disease (IBD) is the dextran sulfate sodium (DSS)‐induced colitis. We have previously reported that 5 days administration of DSS inExpand
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Introduction of aromatic and heteroaromatic groups in the 2-and 8-positions of the Troger's base core by Suzuki, Stille and Negishi cross-coupling reactions - A comparative study
A comparative study on the bis(functionalization) of the Troger's base core by aromatic and heteroaromatic groups using palladium-catalyzed cross-coupling reactions is presented. Three differentExpand
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LL-37-induced human osteoblast cytotoxicity and permeability occurs independently of cellular LL-37 uptake through clathrin-mediated endocytosis.
The host defense peptide LL-37 is cytotoxic for bacteria but it has also been reported to reduce host cell viability through an intracellular mechanism. LL-37-evoked cytotoxicity may be involved inExpand
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Secretory leukocyte protease inhibitor regulates human periodontal ligament cell production of pro-inflammatory cytokines
ObjectiveRegulation of immune-like cell properties of periodontal ligament (PDL) cells is not understood. We investigate the importance of secretory leukocyte protease inhibitor (SLPI) for productionExpand
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Fluorine geochemistry of quaternary deposits in a nemo-boreal catchment with elevated dissolved fluoride in surface waters and groundwater
This study focuses on fluorine (F) concentrations and solid-phase speciation in Quaternary deposits, including till, sorted sediments (gravel, sand, clay/silt) and organic-rich soil types, in an arExpand
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