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Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors.
Vascular Adhesion Protein-1 (VAP-1) is a promising therapeutic target for the treatment of several inflammatory-related diseases including diabetic microvascular complication. We identified glycineExpand
In situ generated (hypo)iodite catalysts for the direct α-oxyacylation of carbonyl compounds with carboxylic acids.
a-Acyloxycarbonyl compounds, which are significant building blocks in synthetic organic chemistry, can traditionally be prepared by the substitution reaction of a-halocarbonyl compounds with alkalineExpand
One-pot synthesis of metalated pyridines from two acetylenes, a nitrile, and a titanium(II) alkoxide.
Four-component coupling process involving two acetylenes, a nitrile, and a divalent titanium alkoxide reagent, Ti(O-i-Pr)(4)/2i-PrMgCl, directly yielded titanated pyridines in a highly selectiveExpand
Titanium Alkoxide-Based Method for Stereoselective Synthesis of Functionalized Conjugated Dienes
Treatment of an internal acetylene such as 1-silyl-1-octyne (3) with a low-valent titanium reagent, (η2-propene)Ti(O-i-Pr)2 (1) readily prepared from Ti(O-i-Pr)4 and i-PrMgCl in situ, generates anExpand
Facile preparation of various heteroaromatic compounds via azatitanacyclopentadiene intermediates.
Coupling of acetylene, nitrile, and a titanium reagent, Ti(O-i-Pr)(4)/2 i-PrMgCl, generated new azatitanacyclopentadienes in a highly regioselective manner. Their subsequent reaction withExpand
Selective syntheses of metalated pyridines from two different unsymmetrical acetylenes, a nitrile, and a titanium(II) alkoxide.
Cyclotrimerization of two different, unsymmetrical acetylenes and p-toluenesulfonylnitrile with a divalent titanium alkoxide reagent, Ti(O-i-Pr)4/2 i-PrMgCl, yielded single pyridyltitanium compoundsExpand
Selective preparation of benzyltitanium compounds by the metalative Reppe reaction. Its application to the first synthesis of alcyopterosin A.
Dialkoxytitanacyclopentadienes, prepared from two different acetylenes and a divalent titanium alkoxide reagent, Ti(O-i-Pr)4/2 i-PrMgCl, reacted with propargyl bromide to give directly benzyltitaniumExpand
Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A
A concise, biomimetic approach to sorbiterrin A has been developed employing consecutive Michael additions of a 4-hydroxypyrone to a sorbicillinol derivative and silver nanoparticle-mediated bridgedExpand