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Selective preparation of benzyltitanium compounds by the metalative Reppe reaction. Its application to the first synthesis of alcyopterosin A.
TLDR
The first synthesis of alcyopterosin A, a bicyclic aromatic sesquiterpenoid recently isolated and characterized, has been achieved by this method, starting with an appropriate combination of an acetylene and a diyne.
In situ generated (hypo)iodite catalysts for the direct α-oxyacylation of carbonyl compounds with carboxylic acids.
TLDR
The a-oxyacetylation of ketones catalyzed by the in situ generated iodine(III) in the presence of an excess amount of BF3·Et2O in wet acetic acid is developed.
One-pot synthesis of metalated pyridines from two acetylenes, a nitrile, and a titanium(II) alkoxide.
TLDR
Four-component coupling process involving two acetylenes, a nitrile, and a divalent titanium alkoxide reagent directly yielded titanated pyridines in a highly selective manner.
Facile preparation of various heteroaromatic compounds via azatitanacyclopentadiene intermediates.
TLDR
Coupling of acetylene, nitrile, and a titanium reagent, Ti(O-i-Pr)(4)/2 i-PrMgCl, generated new azatitanacyclopentadienes in a highly regioselective manner and afforded pyridyltitanium compounds, which, upon reaction with electrophiles, gave substituted pyridines virtually as a single isomer.
Facile preparation of various heteroaromatic compounds via azatitanacyclopentadiene intermediates.
TLDR
Coupling of acetylene, nitrile, and a titanium reagent, Ti(O-i-Pr)(4)/2 i-PrMgCl, generated new azatitanacyclopentadienes in a highly regioselective manner and afforded pyridyltitanium compounds, which, upon reaction with electrophiles, gave substituted pyridines virtually as a single isomer.
Titanium Alkoxide-Based Method for Stereoselective Synthesis of Functionalized Conjugated Dienes
Treatment of an internal acetylene such as 1-silyl-1-octyne (3) with a low-valent titanium reagent, (η2-propene)Ti(O-i-Pr)2 (1) readily prepared from Ti(O-i-Pr)4 and i-PrMgCl in situ, generates an
Selective syntheses of metalated pyridines from two different unsymmetrical acetylenes, a nitrile, and a titanium(II) alkoxide.
TLDR
Cyclotrimerization of two different, unsymmetrical acetylenes and p-toluenesulfonylnitrile with a divalent titanium alkoxide reagent yielded single pyridyltitanium compounds in a highly selective manner that were confirmed by deuteriolysis to give the corresponding deuterated pyridines.
Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A
A concise, biomimetic approach to sorbiterrin A has been developed employing consecutive Michael additions of a 4-hydroxypyrone to a sorbicillinol derivative and silver nanoparticle-mediated bridged
High-performance Hypoiodite/Hydrogen Peroxide Catalytic System for the Oxylactonization of Aliphatic γ-Oxocarboxylic Acids
Highly efficient hypoiodite-catalyzed oxylactonization of aliphatic γ-oxocarboxylic acids to the corresponding γ-acyl-γ-butyrolactones was developed. Highly dilute reaction conditions and slow addi...
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