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Lung Deposition of Aclidinium Bromide from Genuair®, a Multidose Dry Powder Inhaler
Background: Aclidinium bromide is a novel, long-acting inhaled muscarinic antagonist currently in development for the treatment of chronic obstructive pulmonary disease (COPD). A next-generation… Expand
Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite
Background Repeated exposure to inhaled allergen can cause airway inflammation, remodeling and dysfunction that manifests as the symptoms of allergic asthma. We have investigated the role of the… Expand
Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice.
- L. Ciuclan, Kellyann Sheppard, +11 authors K. England
- The American journal of pathology
- 1 November 2013
The expression of the bone morphogenetic protein antagonist, Gremlin 1, was recently shown to be increased in the lungs of pulmonary arterial hypertension patients, and in response to hypoxia.… Expand
AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue
- Alice E. Pollard, L. Martins, +19 authors D. Carling
- Chemistry, Medicine
- Nature metabolism
- 18 January 2019
Obesity results from a chronic imbalance between energy intake and energy output but remains difficult to prevent or treat in humans. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is… Expand
Prevention of pregnancy in bitches following unwanted mating: a clinical trial using low dose oestradiol benzoate.
A field investigation was undertaken in mated bitches to assess the efficacy and safety of a low dose of oestradiol benzoate (0.01 mg kg-1), given by subcutaneous or intramuscular injection, on days… Expand
Keratoconjunctivitis sicca associated with potentiated sulphonamides
Object Interaction Language (OIL): An intent-based language for programming self-organized sensor/actuator networks
- D. Sutton, P. Klein, M. Otte, N. Correll
- Computer Science
- IEEE/RSJ International Conference on Intelligent…
- 3 December 2010
This paper introduces the Object Interaction Language (OIL) that allows programming and coordination of distributed, heterogeneous sensor-actuator networks, such as sensor networks and multi-robot… Expand
The use of hormones, especially progestagens, to control oestrus in bitches.
The transformative power of therapeutic theatre: Enabling health and wellbeing
Staging plays or pantomimes with the aim of personal growth for participants has a long history within mental health occupational therapy practice. This qualitative descriptive study sought to reveal… Expand