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[Lys40(Ahx-DTPA-111In)NH2]exendin-4, a very promising ligand for glucagon-like peptide-1 (GLP-1) receptor targeting.
The high density of GLP-1 receptors in insulinomas as well as the high specific uptake of [Lys(40)(Ahx-DTPA-(111)In)NH(2)]exendin-4 in the tumor of Rip1Tag2 mice indicate that targeting of GLp-1 receptor in insulinoma may become a useful imaging method to localize insulinomas in patients, either preoperatively or intraoperatively. Expand
Aerobic mitochondrial capacities in Antarctic and temperate eelpout (Zoarcidae) subjected to warm versus cold acclimation
Cold compensation of aerobic capacities in the liver seems to be linked to an increase in organ size with unchanged specific mitochondrial protein content, which was found in P. brachycephalum despite its life in permanently cold climate and thus, displayed a capacity for temperature acclimation. Expand
Gene expression profiling in gills of the great spider crab Hyas araneus in response to ocean acidification and warming
The findings indicate a PCO2 dependent threshold beyond which compensation by acclimation fails progressively and indicate a limited ability of this stenoecious crustacean to compensate for the effects of ocean acidification with and without concomitant warming. Expand
Thermal tolerance of crustacean larvae (zoea I) in two different populations of the kelp crab Taliepus dentatus (Milne-Edwards)
The comparison between southern and central populations suggests the adaptation of southern larvae to a colder temperature regime, with higher cardiac outputs due to increased cardiac stroke volumes, larger body sizes but similar body composition as indicated by similar C:N ratios, allows the species to widen its biogeographical range. Expand
Effects of ocean acidification increase embryonic sensitivity to thermal extremes in Atlantic cod, Gadus morhua
It is concluded that ocean acidification constrains the thermal performance window of embryos, which has important implication for the susceptibility of cod to projected climate change. Expand
The impact of ocean warming and acidification on the behaviour of two co-occurring Gadid species, Boreogadus saida and Gadus morhua from Svalbard
This study indicates that fish in polar ecosystems may undergo some, albeit less intense, behavioural disturbances under ocean acidification and in combination with ocean warming than observed in tropical species. Expand
Metabolic Biochemistry: Its Role in Thermal Tolerance and in the Capacities of Physiological and Ecological Function
This chapter discusses the special characteristics of metabolism in the cold by considering their role in tissue and whole‐organism functional adjustments to cold, as well as the environmental forces that cause temperature‐dependent trade‐offs in biochemical and physiological tissue and cellular design. Expand
Thermal tolerance of larval stages of the Chilean kelp crab Taliepus dentatus
Physiological responses of larval stages can differ from those of the adults, affecting key ecological processes. Therefore, developing a mechanistic understanding of larval responses to envi-Expand
Population dynamics and metabolism of Aequipecten opercularis (L.) from the western English Channel (Roscoff, France)
Population dynamics of the queen scallop, Aequipecten opercularis, was investigated in the western English Channel off Roscoff and growth efficiency were in the same range as in other short-lived scallops. Expand
Treatment with 177Lu-DOTATOC of patients with relapse of neuroendocrine tumors after treatment with 90Y-DOTATOC.
Lu-DotATOC therapy in patients with relapse after (90)Y-DOTATOC treatment is feasible, safe, and efficacious, and no serious adverse events occurred. Expand