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Circulating microRNAs as stable blood-based markers for cancer detection
TLDR
It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
TLDR
Identification of extracellular Ago2–miRNA complexes in plasma raises the possibility that cells release a functional miRNA-induced silencing complex into the circulation, and reveals two populations of circulating miRNAs and suggest that circulating Ago2 complexes are a mechanism responsible for the stability of plasma mi RNAs.
The role of FLT3 in haematopoietic malignancies
TLDR
Exploring the mechanism by which mutations in the FLT3 gene cause uncontrolled proliferation might lead to a better understanding of how cells become cancerous and provide insights for the development of new drugs.
Clinical implications of FLT3 mutations in pediatric AML.
TLDR
FLT3 mutation status of 630 children with de novo acute myeloid leukemia (AML) treated on CCG-2941 and -2961 was determined, and ITD-AR was calculated for patients with FLT3/ITD, which defines the prognostic significance in FLT 3/ITd-positive AML.
Quantitative and stoichiometric analysis of the microRNA content of exosomes
TLDR
It is shown here that most exosomes derived from standard preparations do not harbor many copies of miRNA molecules, and are, therefore, individually unlikely to be functional as vehicles for miRNA-based communication.
Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia.
TLDR
Diagnostic bone marrow specimens from 91 pediatric patients with AML were analyzed for the presence of the Flt3/ITD and its presence was the single most significant, independent prognostic factor for poor outcome in pediatric AML.
FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.
TLDR
Results indicate that mutations in FLT3, RAS, or TP53 are common in older patients with AML and are associated with specific AML phenotypes as defined by laboratory values, cytogenetics, and clinical outcomes.
Identification of genes with abnormal expression changes in acute myeloid leukemia
TLDR
Comparing gene expression profiles between normal hematopoietic cells from 38 healthy donors and leukemic blasts from 26 AML patients found that microarray studies could identify previously unrecognized expression changes that occur only in AML blasts.
Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia.
TLDR
Activating mutations in the RTK/ras signaling pathway are common in pediatric AML, and their presence may identify a population at higher risk of poor outcome who may benefit from allogeneic BM transplantation.
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