5-androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression.
Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma.
A unique monoclonal antibody-based drug delivery system, a bifunctional antibody designed to deliver imaging or therapeutic agents, such as radioisotopes, drugs, or biologics, to tumor cells, while minimizing the dose to normal tissue.
5-androstenediol stimulates multilineage hematopoiesis in rhesus monkeys with radiation-induced myelosuppression.
Suppression of tumor growth and enhancement of immune status with high levels of dietary vitamin B6 in BALB/c mice.
- D. Gridley, D. Stickney, R. Nutter, J. Slater, T. Shultz
- Medicine, BiologyJournal of the National Cancer Institute
- 1 May 1987
The data suggest that high dietary intake of vitamin B6 may have suppressed tumor development by either immune enhancement or PLP growth regulation of this tumor.
5-Androstene-3β,17β-diol promotes recovery of immature hematopoietic cells following myelosuppressive radiation and synergizes with thrombopoietin.
Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.
Physicochemical properties, kinetics, and metabolism of a series of lipid-soluble 2,4-diamino-5-phenylpyrimidine folate antagonists, and pharmacokinetic studies in the mouse, rat, dog, and man indicate that metoprine has the longest plasma half-life in all four species.
Flutamide-associated liver toxicity during treatment with total androgen suppression and radiation therapy for prostate cancer.
Flutamide toxicity was common in patients treated with total androgen suppression before and during pelvic radiation therapy (RT) for prostate cancer, and LFTs should be monitored during flutamide therapy.
Enhancement of immune status by high levels of dietary vitamin B-6 without growth inhibition of human malignant melanoma in athymic nude mice.
Despite immune enhancement, tumor incidence and progression was not modified by a high level of dietary vitamin B-6, and it is tempting to speculate that tumor inhibition by high dietary vitaminB-6 may be mediated by T lymphocyte-dependent mechanisms that are lacking in these genetically immuno-deficient mice.
HE3286: A Novel Synthetic Steroid as an Oral Treatment for Autoimmune Disease
- C. Ahlem, D. Auci, F. Nicoletti
- Medicine, BiologyAnnals of the New York Academy of Sciences
- 1 September 2009
HE3286 modulates nuclear factor κB through an unknown mechanism but does not interact with any of the steroid‐binding nuclear hormone receptors and is not immune suppressive, and may provide a new treatment option for patients with inflammatory and autoimmune diseases.
Biologic response modifiers: therapeutic approaches to lymphoproliferative diseases.
Findings dictate ongoing therapy modifications to produce continuing progress in the therapeutic applications of biologic agents in lymphoproliferative disease processes.