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The zebrafish reference genome sequence and its relationship to the human genome
TLDR
A high-quality sequence assembly of the zebrafish genome is generated, made up of an overlapping set of completely sequenced large-insert clones that were ordered and oriented using a high-resolution high-density meiotic map, providing a clearer understanding of key genomic features such as a unique repeat content, a scarcity of pseudogenes, an enrichment of zebra fish-specific genes on chromosome 4 and chromosomal regions that influence sex determination.
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
TLDR
It is shown that the zebrafish silberblick locus encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct convergent extension movements during gastrulation, and that the correct extension of axial tissue is at least partly dependent on medio-lateral cell intercalation in paraxial tissue.
DNA Detection Using Recombination Proteins
TLDR
RPA couples isothermal recombinase polymerase-driven primer targeting of template material with strand-displacement DNA synthesis and achieves exponential amplification with no need for pretreatment of sample DNA, thereby establishing an instrument-free DNA testing system.
Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function.
TLDR
The similarity of normal pronephric development to kidney organogenesis in all vertebrates is revealed and allow for a genetic dissection of genes needed to establish the earliest renal function.
Structure and function of the notochord: an essential organ for chordate development
TLDR
The embryonic origin, signalling roles and ultimate fate of the notochord are discussed, with an emphasis on structural aspects ofNotochord biology.
Zebrafish mutants identify an essential role for laminins in notochord formation.
TLDR
By transplantation, it is demonstrated that, for both grumpy and sleepy, notochord differentiation can be rescued by exogenous sources of the missing laminin chain, although notochordsal sources are also sufficient for rescue.
Multiple mutations in mouse Chd7 provide models for CHARGE syndrome.
TLDR
It is concluded that the large number of mouse mutants and human de novo mutations may be due to the combination of the Chd7 gene being a large target and the fact that many heterozygous carriers of the mutations are viable individuals with a readily detectable phenotype.
A genetic screen for mutations affecting embryogenesis in zebrafish.
TLDR
The results from the first application of such a large-scale genetic screening to vertebrate development of mutagenized zebrafish demonstrate that mutations affecting a variety of developmental processes can be efficiently recovered from zebra fish.
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.
TLDR
It is shown that mbl(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1, which abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription.
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