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Temperature-responsive silk-elastinlike protein polymer enhancement of intravesical drug delivery of a therapeutic glycosaminoglycan for treatment of interstitial cystitis/painful bladder syndrome.
Interstitial cystitis (IC), also known as painful bladder syndrome, is a debilitating chronic condition with many patients failing to respond to current treatment options. Rapid clearance, mucosal… Expand
Location of stimuli-responsive peptide sequences within silk-elastinlike protein-based polymers affects nanostructure assembly and drug–polymer interactions
- Kyle J Isaacson, M. Jensen, +5 authors H. Ghandehari
- Chemistry, Medicine
- Journal of drug targeting
- 20 April 2020
Abstract Silk-elastinlike protein polymers (SELPs) self-assemble into nanostructures when designed with appropriate silk-to-elastin ratios. Here, we investigate the effect of insertion of a matrix… Expand
Matrix Mediated Viral Gene Delivery: A Review.
Polymeric matrices inherently protect viral vectors from pre-existing immune conditions, limit dissemination to off-target sites, and can sustain vector release. Advancing methodologies in… Expand
A dual-functional Embolization-Visualization System for Fluorescence image-guided Tumor Resection
Rationale: Intraoperative bleeding impairs physicians' ability to visualize the surgical field, leading to increased risk of surgical complications and reduced outcomes. Bleeding is particularly… Expand
Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis.
- D. Steinhauff, M. Jensen, +6 authors H. Ghandehari
- Journal of controlled release : official journal…
- 7 March 2021
Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy. The lack of prophylactic treatment strategies leads to diminished patient… Expand
Reaktionen von unterschiedlich akklimatisierten laktierenden Kühen auf eine Wärmebelastung1, 2: 1. Mitteilung Leistung und Thermoregulation