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Interdomain association in fibronectin: insight into cryptic sites and fibrillogenesis
The process by which fibronectin (FN), a soluble multidomain protein found in tissue fluids, forms insoluble fibrillar networks in the extracellular matrix is poorly understood. Cryptic sites foundExpand
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The hairpin structure of the 6F11F22F2 fragment from human fibronectin enhances gelatin binding
The solution structure of the 6F11F22F2 fragment from the gelatin‐binding region of fibronectin has been determined (Protein Data Bank entry codes 1e88 and 1e8b). The structure reveals an extensiveExpand
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Crystal structure of a cytokine‐binding region of gp130
The structure of the cytokine‐binding homology region of the cell surface receptor gp130 has been determined by X‐ray crystallography at 2.0 Å resolution. The β sandwich structure of the two domainsExpand
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Motogenic Sites in Human Fibronectin Are Masked by Long Range Interactions
Fibronectin (FN) is a large extracellular matrix glycoprotein important for development and wound healing in vertebrates. Recent work has focused on the ability of FN fragments and embryonic orExpand
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The crystal structure and biological function of leukemia inhibitory factor: Implications for receptor binding
The structure of murine leukemia inhibitory factor (LIF) has been determined by X-ray crystallography at 2.0 A resolution. The main chain fold conforms to the four alpha-helix bundle topologyExpand
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The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors
Summary Adhesion class G protein-coupled receptors (aGPCR) form the second largest group of seven-transmembrane-spanning (7TM) receptors whose molecular layout and function differ from canonical 7TMExpand
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Structure and Function of the Escherichia coli Tol-Pal Stator Protein TolR*
Background: TolR forms part of the proton-motive force (pmf)-linked stator of the Tol-Pal complex in bacteria. Results: Structural and biophysical analysis shows the periplasmic domain of TolR to beExpand
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Dopamine receptor changes following destruction of the nigrostriatal pathway: Lack of a relationship to rotational behavior
Phenomena consistent with postsynaptic supersensitivity developed in the rat neostriatum following the destruction of dopaminergic afferent neurons. A gradual increase in the density of binding sitesExpand
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Cell‐free expression and selective isotope labelling in protein NMR
Isotope labelling is a very powerful tool in NMR studies of proteins and has been employed in various ways for over 40 years. 15N and 13C incorporation, using recombinant expression systems, is nowExpand
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Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules
Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is a keyExpand
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