• Publications
  • Influence
Intracellular receptors use a common mechanism to interpret signaling information at response elements.
The glucocorticoid receptor (GR) activates transcription in certain glucocorticoid response element (GRE) contexts, and represses or displays no activity in others. We isolated point mutations in oneExpand
  • 120
  • 5
A Weak TATA Box Is a Prerequisite for Glucocorticoid-dependent Repression of the Osteocalcin Gene*
The TATA box element is not only important for establishing basal levels of transcription, but it can also be used to modulate cell type or stage specific gene activity. In the case of the humanExpand
  • 83
  • 3
The Rat Glucocorticoid Receptor Mutant K461A Differentiates between Two Different Mechanisms of Transrepression*
The glucocorticoid receptor (GR) can both activate and repress transcription of target genes by interaction with specific genomic response elements, glucocorticoid response elements (GREs).Expand
  • 29
  • 2
Secret Thoughts of an Adoptive Mother
  • 4
  • 2
Expression Level-Dependent Contribution of Glucocorticoid Receptor Domains for Functional Interaction with STAT5
ABSTRACT The action of the glucocorticoid receptor (GR) on β-casein gene transcription serves as a well-studied example of a case where the action of the GR is dependent on the activity of anotherExpand
  • 51
  • 1
  • PDF
Breastfeeding and Adoption
  • 1
Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.
Cyclin D1 is expressed at abnormally high levels in many cancers and has been specifically implicated in the development of breast cancer. In this report we have extensively analyzed the cyclin D1Expand
  • 10