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C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS
TLDR
This study demonstrates the large and consistent impact of the thermolabile MTHFR variant on plasma homocysteine levels in different European populations, and shows a regional difference in the levels of homocy steine that must be explained by other genetic or environmental factors. Expand
Regulation of mammalian pyruvate dehydrogenase
TLDR
It is presented that in both adipose tissue and heart muscle, differences in activity of pyruvate dehydrogenase in the intact tissue persist during preparation and subsequent incubation of mitochondria. Expand
Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men.
TLDR
An interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate. Expand
Association of socioeconomic position with insulin resistance among children from Denmark, Estonia, and Portugal: cross sectional study
TLDR
Among Danish children, those with the most educated and highest earning parents had least insulin resistance, whereas the opposite was true for children from Estonia and Portugal. Expand
Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed
TLDR
Although changes in rates of fatty acid synthesis were found, the initial activity of pyruvate dehydrogenase did not alter, but small parallel changes in acetyl-CoA carboxylase activity were observed. Expand
The association of birthweight and contemporary size with insulin resistance among children from Estonia and Denmark: findings from the European Youth Heart Study
TLDR
Assessment of the associations of birthweight, contemporary body mass index and height with insulin resistance in children and the use of insulin resistance medication in children shows clear associations with diabetes in children. Expand
Defect in the lipoyl-bearing protein X subunit of the pyruvate dehydrogenase complex in two patients with encephalomyelopathy.
TLDR
This is the second description of an encephalomyelopathy associated with a specific absence of the lipoyl-containing protein X component, which has a structural role in the formation of a functional PDHC. Expand
Neonatal Parenteral Nutrition with a Fat Emulsion Containing Medium Chain Triglycerides
TLDR
The group who received the emulsion containing medium chain triglycerides had significantly lower mean plasma cholesterol values during the study, and after 6 days of intravenous fat administrationmean plasma cholesterol was more than 100% higher in the group which received the conventional emulsion. Expand
Blood spot homocysteine: a feasibility and stability study.
Homocystinuria is an autosomal recessive disorder usually caused by deficiency of cystathionine β-synthase, leading to grossly increased plasma and urine concentrations of homocysteine. There isExpand
Regulation of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase activity in rat epididymal fat-pads. Effects of starvation, alloxan-diabetes and high-fat diet.
TLDR
The extramitochondrial activity of pyruvate dehydrogenase phosphate phosphatase in rat epididymal fat-pads was sensitive to activation by Ca2+, but perhaps less sensitive than the mitochondrial activity. Expand
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