• Publications
  • Influence
Cytotoxic activity of some phenanthroindolizidine N-oxide alkaloids from Cynanchum vincetoxicum.
TLDR
Two previously known phenanthroindolizidine alkaloids and a novel alkaloid were isolated from aerial parts of Cynanchum vincetoxicum, demonstrating that these compounds are poor substrates for the P-glycoprotein (P-170) efflux pump. Expand
In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells.
TLDR
The IC(50) values of some of the alkaloids are in the low nanomolar range, being thus comparable to the activity of clinically used cytotoxic drugs, and could possibly be overcome by modern tissue-specific drug targeting techniques. Expand
Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis
TLDR
Stereoselective biosynthesis of over 50 diterpene skeletons was demonstrated, including natural variants and novel enantiomeric or diastereomeric counterparts, and Scalable biotechnological production for four industrially relevant targets was accomplished in engineered strains of Saccharomyces cerevisiae. Expand
Two Novel Classes of Enzymes Are Required for the Biosynthesis of Aurofusarin in Fusarium graminearum*
TLDR
Functional information is provided on two novel classes of proteins and their contribution to polyketide pigment biosynthesis in Fusarium graminearum and aurZ and aurS. Expand
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues.
TLDR
The established link between erythrocyte membrane modifications and antiplasmodial activity may provide a novel target for potential antimalarial drugs. Expand
Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones.
TLDR
The findings provide a rationale for traditional use of the roots of Perovskia abrotanoides as a constituent of poultices for treatment of cutaneous leishmaniasis. Expand
New resistance-correlated saponins from the insect-resistant crucifer Barbarea vulgaris.
TLDR
This study isolated three new constituents of Brassicaceae from the glabrous type of Barbarea vulgaris var. Expand
Terpenoids of Salvia hydrangea: two new, rearranged 20-norabietanes and the effect of oleanolic acid on erythrocyte membranes.
TLDR
Four abietane-type terpenoids, including two known royleanones and two new, rearranged 20-norabietanes, were isolated from the roots of the Iranian medicinal plant Salvia hydrangea DC, and oleanolic acid caused transformation of erythrocytes into stomatocytes in the concentration range where the in vitro antiplasmodial activity was observed. Expand
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
TLDR
The first phytochemical investigation of the recently discovered East African liana Ancistrocladus tanzaniensis is described, resulting in the isolation and structural elucidation of two new naphthylisoquinoline alkaloids and a hitherto unprecedented 5,3'-coupling type between the naphthalene and isoquinoline portions. Expand
Screening for potential α-glucosidase and α-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes.
TLDR
Corilagin, repandusinic acid A, and mallotinin were potent α-glucosidase inhibitors contributing significantly to the inhibitory effect observed for the water extracts of P. amarus and P. urinaria. Expand
...
1
2
3
4
5
...