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In Vitro Plasmodium falciparum Drug Sensitivity Assay: Inhibition of Parasite Growth by Incorporation of Stomatocytogenic Amphiphiles into the Erythrocyte Membrane
TLDR
The antiplasmodial activity of lupeol appears to be indirect, being due to stomatocytic transformation of the host cell membrane and not to toxic effects via action on a drug target within the parasite. Expand
The Antiparasitic Compound Licochalcone A Is a Potent Echinocytogenic Agent That Modifies the Erythrocyte Membrane in the Concentration Range Where Antiplasmodial Activity Is Observed
TLDR
In vitro experiments with synchronous cultures demonstrate that inhibition of invasion is the principal mechanism of growth inhibition and the erythrocyte membrane-modifying effect was also transiently observed in vivo in mice after intravenous administration. Expand
Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.
TLDR
It is demonstrated that analogues of the natural product sinefungin lacking the amino acid moiety constitute an interesting scaffold to develop selective methyltransferase inhibitors and the inhibition was not competitive toward AdoMet. Expand
HPLC–SPE–NMR hyphenation in natural products research: optimization of analysis of Croton membranaceus extract
TLDR
The sensitivity gain provided by the HPLC–SPE–NMR technique through repeated peak trappings allowed the acquisition of good‐quality proton‐detected 2D NMR spectra without the need for solvent suppression. Expand
Selagoline, A new Alkaloid from Huperzia Selago
TLDR
A new natural product, named selagoline, and two known alkaloids, huperzine A and serratidine, were isolated from Huperzia selago (Lycopodiaceae) collected in Iceland using 600 and 800 MHz one- and two-dimensional NMR methods supported by Fourier-transform mass spectrometry. Expand
Structural analysis of complex saponins of Balanites aegyptiaca by 800 MHz 1H NMR spectroscopy
TLDR
This work represents a new approach to structural elucidation of saponins: direct preparative‐scale HPLC‐RID of crude extracts followed by high‐field NMR investigations supported by ESI‐MSn. Expand
Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol
TLDR
This study elucidates the early steps of celastrol biosynthesis and paves the way for future biotechnological production of this pharmacologically promising compound in engineered yeast strains. Expand
Naravelia zeyanica: occurrence of primary benzamides in flowering plants
Extract of Naravelia zeylanica (Ranunculaceae) yielded three simple benzamides, 3,4-methylenedioxybenzamide, 4-methoxybenzamide and 4-hydroxy-3-methoxybenzamide. These simple C6C1 metabolites haveExpand
Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila
TLDR
This work investigated the metabolite diversity in a chemo-evolutionary framework applying a combination of molecular phylogenetic and state-of-the-art computational metabolomics tools to build a dataset involving leaf samples from a total of 291 specimens of Eremophila and allied genera. Expand
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