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Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements.
TLDR
The methods of measuring cell and fluid phase markers in induced sputum used in this study are reproducible and valid and can therefore be used to reliably measure these indices of airway inflammation.
Fatal food-induced anaphylaxis.
TLDR
Food-sensitive individuals must self-administer epinephrine promptly at the first sign of systemic reaction, and emergency care providers should be aware of cricothyrotomy as a life-saving procedure.
Laboratory investigation of deaths due to anaphylaxis.
TLDR
Elevated mast-cell-derived tryptase levels in postmortem sera reflect antemortem mast cell activation and may be used as a marker for fatal anaphylaxis, and IgE antibodies were moderately stable during storage in a variety of anticoagulants at room temperature for up to 11 weeks.
An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein
A histologic hallmark of chronic rhinosinusitis (CRS) is an eosinophilic inflammation, present with and without nasal polyposis and independent of atopy. Eosinophils migrate through nasal tissue
Shared allergenic activity in Asian (Blattella asahinai), German (Blattella germanica), American (Periplaneta americana), and Oriental (Blatta orientalis) cockroach species.
TLDR
In crossover radioallergosorbent inhibition analysis, the Asian cockroach shared allergenic activity primarily with the German cockroach polymer and to a lesser extent with either the American or Oriental cockroach polymers.
Oxidative stress serves as a key checkpoint for IL‐33 release by airway epithelium
TLDR
The transcription factor nuclear factor‐erythroid‐2‐related factor 2 (Nrf2) plays a key role in antioxidant response regulation and is implicated in the pathophysiology of asthma and allergic diseases.
Regulation of TLR2 Expression and Function in Human Airway Epithelial Cells
TLDR
It is demonstrated that upregulation of TLR2 following exposure to dsRNA enhances functional responses of the airway epithelium to certain (PAM3CSK4), but not all (zymosan, LTA) TLR 2 ligands and that this is likely due to differences in coreceptor expression.
Eosinophil cationic protein relates to sputum neutrophil counts in healthy subjects.
Fungal allergen‐induced IL‐33 secretion involves cholesterol‐dependent, VDAC‐1‐mediated ATP release from the airway epithelium
TLDR
A novel role is established for VDAC‐1 as a mechanism underlying ATP release induced by fungal allergens and a possible therapeutic use for cholesterol lowering compounds in reducing Alternaria‐stimulated allergic inflammation is suggested.
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