D. Springall

Publications152
h-index50
Citations7,529
Highly Influential Citations124
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Localization of nitric oxide synthase in the adult rat brain.
The distribution of the immunoreactivity to nitric oxide synthase has been examined from rostral to caudal areas of the rat central nervous system using light microscopy. Endogenous nitric oxide… Expand
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An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 in man and commonly employed laboratory animals.
The cutaneous nerves of rat, cat, guinea pig, pig, and man were studied by immunocytochemistry to compare the staining potency of general neural markers and to investigate the density of nerves… Expand
  • 140
  • 10
Ontogeny of peptide‐ and amine‐containing neurones in motor, sensory, and autonomic regions of rat and human spinal cord, dorsal root ganglia, and rat skin
The developmental patterns of neurofilament triplet proteins, peptide and amine immunoreactivities were compared in motor (ventral spinal cord), sensory (dorsal spinal cord, dorsal root ganglia,… Expand
  • 256
  • 7
Expression of inducible nitric oxide in human lung epithelial cells.
Nitric oxide (NO) is increased in the exhaled air of subjects with several airway disorders. To determine if cytokines could stimulate epithelial cells accounting for the increased NO, the capacity… Expand
  • 343
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Retrograde tracing shows that CGRP-immunoreactive nerves of rat trachea and lung originate from vagal and dorsal root ganglia.
The origins of sensory innervation of the lower respiratory tract are thought to be principally the nodose and jugular ganglia of the vagus nerve. It has been suggested and partially demonstrated… Expand
  • 149
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High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension
The pathogenesis of pulmonary hypertension (PH) remains poorly understood. Vasoconstriction, although likely to be a major factor in the disease, varies between patients and studies of a variety of… Expand
  • 144
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Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans.
Neuropeptides released from sensory nerves during inflammation have potent effects on bronchomotor tone, airway secretion, and inflammatory cells. We investigated the effects of ozone on sensory… Expand
  • 69
  • 4
Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation.
Nitric oxide (NO) is detectable in exhaled air. To elucidate whether airway epithelial cells could be a source of NO, we investigated the expression of inducible nitric oxide synthase (iNOS) by the… Expand
  • 204
  • 3
Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy
BACKGROUND Two important features of dilated cardiomyopathy (DCM) are low myocardial contractility and risk of thromboembolism. Nitric oxide (NO) exerts a negative inotropic effect on the myocardium… Expand
  • 307
  • 3
Immunohistochemical demonstration of human cardiac innervation before and after transplantation.
Knowledge about the distribution and origins of peptide-containing nerves in the innervated and transplanted heart is lacking. Immunohistochemical and histochemical techniques were used to visualize… Expand
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