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Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response*
This study addressed the underlying mechanism for variable expression of ATF4 in response to eIF2∼P during different stress conditions and the biological significance of omission of enhanced ATF4 function, and showed that in addition to translational control, ATF4 expression is subject to transcriptional regulation. Expand
The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer
The studies provide further evidence for a role of the IGF-1 receptor (IGF-1R) in suppressing UVB-induced carcinogenesis, suggest that fibroblasts have a critical role in maintaining appropriate activation of the keratinocyte IGF- 1R, and imply that reduced expression in geriatric skin could be an important component in the development of aging-related non-melanoma skin cancer. Expand
Primary cilia signaling mediates intraocular pressure sensation
  • Na Luo, M. Conwell, +11 authors Y. Sun
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 30 April 2014
It is shown that TM cells, which are defective in glaucoma, have primary cilia that are critical for response to pressure changes, implicated in how the eye senses pressure changes and highlights OCRL and TRPV4 as attractive therapeutic targets for the treatment of glAUcoma. Expand
Aberrant NF-κB Activity in HaCaT Cells Alters their Response to UVB Signaling
It is demonstrated that NF- κ B DNA binding is activated by both UVB and TNF α, but discrepancies in the activation of key upstream signaling pathway components such as AKT phosphorylation and I λ B α degradation exist. Expand
UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53.
It is demonstrated that activation of the IGF-1R promotes the premature senescence of UVB-irradiated keratinocytes through increased generation of reactive oxygen species (ROS) and by maintaining the expression of the cyclin-dependent kinase inhibitor p21(CDKN1A). Expand
Ultraviolet B Radiation Generates Platelet-activating Factor-like Phospholipids underlying Cutaneous Damage*
UVB photo-oxidizes cellular phospholipids, creating PAF analogs that stimulate the PAF receptor to induce further PAF synthesis and apoptosis, and concludes PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses. Expand
The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth
A mechanism whereby the PAF-R can exert proliferative effects through the activation of the EGF-R is provided, and it is shown that theactivation of the PAFs stimulates the replication of epidermal cells. Expand
Pten loss induces autocrine FGF signaling to promote skin tumorigenesis.
Autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors is identified as well as genetic disruption of the mTORC1 complex which prevents skin tumorigenesis in Pten mutants. Expand
trans-activation of viral enhancers by the hepatitis B virus X protein
It is demonstrated that SV40 T-ag can suppress trans-activation by the X protein, which is capable of trans-activating the simian virus 40 (SV40) and Rous sarcoma virus enhancers (pSV2cat and pRSVcat) in CV-1 cells. Expand
Activation of the insulin‐like growth factor‐1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation
It is found that the only growth factor that provided protection from UVB‐induced apoptosis was insulin and that the protective effect elicited by insulin was not due to binding the insulin receptor but, rather, to activation of the insulin‐like growth factor‐1 (IGF‐1) receptor. Expand