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Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury.
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Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat
TLDR
Both fucoidin and UK74505 prevented the local, but not systemic, increases of TNF‐α levels following severe I/R injury, demonstrating an important role of migrating cells for the local production of T NF‐α, however, the results do not support a role for PAF as an intermediate molecule in the production of systemic TNF-α.
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Commensal microbiota is fundamental for the development of inflammatory pain
TLDR
Results show that contact with commensal microbiota is necessary for mice to develop inflammatory hypernociception, and implicate an important role of the interaction between the commensAL microbiota and the host in favoring adaptation to environmental stresses, including those that cause pain.
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Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection
TLDR
The results demon‐strated the contribution of MIF to the pathogenesis of dengue and pointed to a possible beneficial role of neutralizing MIF as an adjunctive therapeutic approach to treat the severe forms of the disease.
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The Required Role of Endogenously Produced Lipoxin A4 and Annexin-1 for the Production of IL-10 and Inflammatory Hyporesponsiveness in Mice1
TLDR
The data demonstrate that inflammatory responsiveness is tightly controlled by the presence of the microbiota and that the innate capacity of germfree mice to produce IL-10 is secondary to their endogenous greater ability to produce lipoxin A4 and annexin-1.
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Phosphoinositide‐3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation
TLDR
An important role of PI3Kγ for the maintenance of eosinophilic inflammation in vivo is demonstrated, whereas other isoforms ofPI3K may be relevant for the recruitment process.
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The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.
TLDR
Treatment with glibenclamide is associated with inhibition of neutrophil recruitment and amelioration of renal dysfunction following renal I/R, and may have a therapeutic role in the treatment of renal I-R injury, such as after renal transplantation.
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Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection
Severe dengue infection in humans causes a disease characterized by thrombocytopenia, increased levels of cytokines, increased vascular permeability, hemorrhage, and shock. Treatment is supportive.…
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The Essential Role of the Intestinal Microbiota in Facilitating Acute Inflammatory Responses1
TLDR
The lack of intestinal microbiota is accompanied by a state of active IL-10-mediated inflammatory hyporesponsiveness, consistent with the prevention of reperfusion-associated injury by the exogenous administration of IL- 10 to conventional mice.
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Effects of inhibition of PDE4 and TNF‐α on local and remote injuries following ischaemia and reperfusion injury
TLDR
The capacity of PDE4 inhibitors to block the recruitment of neutrophils into tissues, the production of LTB4 and of the pro‐inflammatory cytokines TNF‐α, IL‐1ß and IL‐6 appear to underlie their anti‐inflammatory effects in the authors' model of I/R injury.
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