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Caffeine and adenosine A2a receptor antagonists prevent β-amyloid (25–35)-induced cognitive deficits in mice
- O. Dall’igna, Paulo Fett, M. W. Gomes, D. Souza, R. Cunha, D. Lara
- MedicineExperimental Neurology
- 31 January 2007
First direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer's disease is provided.
Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity.
- M. Aschner, T. Syversen, D. Souza, J. Rocha, M. Farina
- Chemistry, MedicineBrazilian journal of medical and biological…
- 1 March 2007
This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity by examining the role of oxidative stress in mediating neuronal damage and provides a mechanistic overview on oxidative stress induced by MeHg that is triggered by a series of molecular events such as activation of various kinases, stress proteins and other immediate early genes culminating in cell damage.
Chronically administered guanosine is anticonvulsant, amnesic and anxiolytic in mice
- E. Vinadé, A. Schmidt, M. Frizzo, I. Izquierdo, E. Elisabetsky, D. Souza
- MedicineBrain Research
- 4 July 2003
Analysis of the effects of 2 weeks ad libitum consumption of guanosine added to mice water supply on seizures and lethality induced by the alpha-dendrotoxin, hole-board behavior, inhibitory avoidance task, locomotor activity, motor coordination, rectal temperature, body weight, and water and food consumption suggests a potential role for chronic Guanosine in the management of diseases associated with glutamatergic excitotoxicity.
Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
- M. Dietrich, C. Antunes, +9 authors T. Horvath
- Biology, MedicineThe Journal of Neuroscience
- 1 September 2010
It is shown in mice that a central regulatory component in energy metabolism, the hypothalamic melanocortin system, is affected by Sirt1, which promotes the activity and connectivity of this system resulting in negative energy balance.
Proposal of a guanine-based purinergic system in the mammalian central nervous system.
Findings point to the guanine-based purines (nucleotides and guanosine) as potential new targets for neuroprotection and neuromodulation.
Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics.
- Rodrigo W Grillo, G. L. Ottoni, R. Leke, D. Souza, L. Portela, D. Lara
- Psychology, MedicineJournal of psychiatric research
The results reinforce previous findings of reduced serum BDNF levels in schizophrenic patients and suggest a differential effect of clozapine compared to typical antipsychotics on such levels.
Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult mice
- P. Botton, Marcelo S. Costa, +4 authors L. Porciúncula
- Medicine, PsychologyBehavioural Brain Research
- 25 December 2010
It is suggested that acute treatment with caffeine followed by its withdrawal may be effective against cholinergic-induced disruption of memory assessed in an aversive and non-aversive task and revealed that the Cholinergic system is involved in the positive effects of caffeine on cognitive functions.
Increased serum S100B protein in schizophrenia: a study in medication-free patients.
The results of this study indicate that serum S100B levels may be a state marker of a limited neurodegenerative process, particularly in the early course of schizophrenia or, at least, in a subgroup of schizophrenic patients.
Guanosine and GMP prevent seizures induced by quinolinic acid in mice
Anticonvulsant properties of i.p. guanosine and GMP are suggested, which may be related with antagonism of glutamate receptors, in mice implicated in the neurobiology of seizures.
Behavioral effects of taurine pretreatment in zebrafish acutely exposed to ethanol
- D. B. Rosemberg, Marcos M Braga, +10 authors D. Souza
- Medicine, ChemistryNeuropharmacology
- 1 September 2012
The data suggest that both protocols of acute EtOH exposure induce significant changes in the spatio-temporal behavior of zebrafish and that TAU may exert a preventive role by antagonizing the effects induced by EtOH possibly due to its neuromodulatory role and also by decreasing brain EtOH levels.