D. Souza

Publications465
h-index57
Citations11,738
Highly Influential Citations406
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Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity.
This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings… Expand
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Caffeine and adenosine A2a receptor antagonists prevent β-amyloid (25–35)-induced cognitive deficits in mice
Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured neurons against… Expand
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Proposal of a guanine-based purinergic system in the mammalian central nervous system.
Guanine-based purines have been traditionally studied as modulators of intracellular processes, mainly G-protein activity. However, they also exert several extracellular effects not related to G… Expand
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Chronically administered guanosine is anticonvulsant, amnesic and anxiolytic in mice
Acute administration of intraperitoneal and oral guanosine has been shown to prevent quinolinic acid and alpha-dendrotoxin-induced seizures in rats and mice. In this study, we investigated the… Expand
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Increased serum S100B protein in schizophrenia: a study in medication-free patients.
S100B protein, a calcium binding protein produced and released by glial cells, has been used as a sensitive marker of brain damage. Previous studies have found alterations in peripheral S100B levels… Expand
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Behavioral effects of taurine pretreatment in zebrafish acutely exposed to ethanol
Taurine (TAU) is an amino sulfonic acid that plays protective roles against neurochemical impairments induced by ethanol (EtOH). Mounting evidence shows the applicability of zebrafish for evaluating… Expand
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Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics.
Neurotrophic factors regulate neuronal development and synaptic plasticity, possibly playing a role in the pathophysiology of schizophrenia and other psychiatric disorders. Decreased brain-derived… Expand
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Guanosine and GMP prevent seizures induced by quinolinic acid in mice
In the mammalian CNS, glutamate and GABA are the principal neurotransmitters mediating excitatory and inhibitory synaptic events, respectively, and have been implicated in the neurobiology of… Expand
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Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain.
During the perinatal period, the central nervous system (CNS) is extremely sensitive to metals, including methylmercury (MeHg). Although the mechanism(s) associated with MeHg-induced developmental… Expand
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Anticonvulsant effect of GMP depends on its conversion to guanosine
Studies on the purinergic system normally deal with adenine-based purines, namely, adenine nucleotides and adenosine. However, a guanine-based purinergic system may also have important… Expand
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