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- Publications
- Influence
Envelope Protein Glycosylation Status Influences Mouse Neuroinvasion Phenotype of Genetic Lineage 1 West Nile Virus Strains
- D. Beasley, Melissa C. Whiteman, +7 authors A. Barrett
- Biology, Medicine
- Journal of Virology
- 1 July 2005
ABSTRACT The introduction of West Nile virus (WNV) into North America has been associated with relatively high rates of neurological disease and death in humans, birds, horses, and some other… Expand
The pathogenesis of Rift Valley fever virus in the mouse model.
- D. Smith, K. Steele, +6 authors L. Hensley
- Biology, Medicine
- Virology
- 25 November 2010
Detailed studies describing the pathogenesis of Rift Valley fever (RVF) virus (RVFV) in the mouse model are lacking. A fully characterized small animal model of RVF is needed to evaluate potential… Expand
Evaluation of methods to assess transmission potential of Venezuelan equine encephalitis virus by mosquitoes and estimation of mosquito saliva titers.
- D. Smith, A. Carrara, P. Aguilar, S. Weaver
- Biology, Medicine
- The American journal of tropical medicine and…
- 1 July 2005
Determining the dose of an arbovirus transmitted by a mosquito is important to design transmission and pathogenesis studies simulating natural infection. Several different artificial infection and… Expand
Venezuelan equine encephalitis virus in the mosquito vector Aedes taeniorhynchus: infection initiated by a small number of susceptible epithelial cells and a population bottleneck.
- D. Smith, A. Adams, Joan L. Kenney, E. Wang, S. Weaver
- Biology, Medicine
- Virology
- 1 March 2008
We evaluated infection of Aedes taeniorhynchus mosquitoes, vectors of Venezuelan equine encephalitis virus (VEEV), using radiolabeled virus and replicon particles expressing green (GFP) or cherry… Expand
Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon
- D. Smith, Bradley S. Hollidge, +14 authors J. W. Golden
- Biology, Medicine
- PLoS neglected tropical diseases
- 1 January 2017
Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient… Expand
Development of field-based real-time reverse transcription-polymerase chain reaction assays for detection of Chikungunya and O'nyong-nyong viruses in mosquitoes.
- D. Smith, J. Lee, +4 authors M. O’guinn
- Medicine, Biology
- The American journal of tropical medicine and…
- 1 October 2009
Chikungunya (CHIK) and O'nyong-nyong (ONN) are important emerging arthropod-borne diseases. Molecular diagnosis of these two viruses in mosquitoes has not been evaluated, and the effects of… Expand
Development of a Novel Nonhuman Primate Model for Rift Valley Fever
- D. Smith, B. Bird, +9 authors L. Hensley
- Biology, Medicine
- Journal of Virology
- 7 December 2011
ABSTRACT Rift Valley fever (RVF) virus (RVFV) can cause severe human disease characterized by either acute-onset hepatitis, delayed-onset encephalitis, retinitis and blindness, or a hemorrhagic… Expand
Mosquitoes Transmit Unique West Nile Virus Populations during Each Feeding Episode.
- N. Grubaugh, J. Fauver, +7 authors G. Ebel
- Biology, Medicine
- Cell reports
- 25 April 2017
Arthropod-borne viruses (arboviruses), such as Zika virus, chikungunya virus, and West Nile virus (WNV), pose continuous threats to emerge and cause large epidemics. Often, these events are… Expand
Experimental Evolution of an RNA Virus in Wild Birds: Evidence for Host-Dependent Impacts on Population Structure and Competitive Fitness
- N. Grubaugh, D. Smith, +13 authors G. Ebel
- Biology, Medicine
- PLoS pathogens
- 1 May 2015
Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is reduced by stochastic and… Expand
A novel sheet-like virus particle array is a hallmark of Zika virus infection
- J. Liu, Brandon A Kline, +10 authors X. Zeng
- Biology, Medicine
- Emerging Microbes & Infections
- 25 April 2018
Zika virus (ZIKV) is an emerging flavivirus that caused thousands of human infections in recent years. Compared to other human flaviviruses, ZIKV replication is not well understood. Using… Expand