• Publications
  • Influence
Lipid digestion and absorption.
The physical chemistry of lipids : from alkanes to phospholipids
TLDR
This book is oriented toward understanding the structure, function, and behavior of lipids in biological systems, concentrating in particular on the changes in state and structure that occur with changes in temperature and during lipid-water and lipid-lipid interactions.
The physicochemical basis of cholesterol gallstone formation in man.
TLDR
The physical state of bile is suggested that the presence or absence of insoluble cholesterol is determined by the relative concentrations of biles salt, lecithin, and cholesterol, and the other biliary constituents do not appear to significantly effect the solubility of cholesterol in bile.
Nature of the Thermal pretransition of synthetic phospholipids: dimyristolyl- and dipalmitoyllecithin.
TLDR
The hydrated synthetic lecithins, dimyristoyl and dipalmitoyllecithin, undergo two thermal transitions, a broad low enthalpy "pretransition" prior to the sharp first-order "chain-melting" transition and a structural transformation from a one-dimensional lamellar to a two-dimensional monoclinic lattice consisting of lipid lamellae distorted by a periodic ripple.
Phase equilibria and structure of dry and hydrated egg lecithin.
  • D. Small
  • Physics
    Journal of lipid research
  • 1 November 1967
TLDR
The behavior of purified egg lecithin in water has been investigated in relation to the quantity of water present and the temperature and calculations suggest that the reason for this may be the presence of a "free water layer" when more than 16% water is present.
The effects of glyceride structure on absorption and metabolism.
  • D. Small
  • Biology
    Annual review of nutrition
  • 1991
TLDR
The metabolism of a few key stereospecific triacylglycerols in more detail is studied to increase the understanding of their effects on hypercholesterolemia and atherogenesis.
Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule.
TLDR
The phase behavior of several medium-chain and long-chain fatty acids in water was examined as a function of the ionization state of the carboxyl group to provide insights into the physical states of fatty acid in biological systems.
The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.
TLDR
The results demonstrate that cholesterol gallstone patients have supersaturated gallbladder and hepatic biles without exception, and the predominant driving force for cholesterol precipitation appears to be the absolute degree of cholesterol supersaturation.
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