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Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.
Those patients who had the largest increases in 47Ca-kinetic and histomorphometric indices of new bone formation showed the greatest increases in trabecular bone volume, suggesting that treatment with human parathyroid hormone fragment caused a dissociation between formation and resorption rates that was confined to trabECular bone. Expand
Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25‐dihydroxyvitamin D
Results indicate that increasing intestinal absorption of dietary calcium while simultaneously stimulating new bone formation with small doses of parathyroid hormone can restore spinal bone in osteoporotic men. Expand
Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients.
It is possible that a deficiency in 1,25-(OH)2-D secretory reserve will explain the inability of elderly osteoporotic patients to adapt to the low-calcium diets common in this age group and this phenomenon may play a part in the pathogenesis of age-related osteoporeosis. Expand
Treatment of postmenopausal osteoporosis with daily parathyroid hormone plus calcitriol
An ideal treatment for osteoporosis would increase bone strength by increasing the amount of mineralized lamellar bone, the thickness of cortical bone, and the connectivity of trabecutar bone, andExpand
Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting.
It is demonstrated that serum osteocalcin levels are normal in disorders not involving bone, can be used in a general-hospital setting, where concomitant illnesses are present, and may provide additional information for the clinical evaluation of metabolic bone disease. Expand
Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor.
A patient with autoimmune hyperparathyroidism and hypocalciuric hypercalcemia caused by IgG4 autoantibodies directed against the calcium-sensing receptor responded to the administration of glucocorticoids. Expand
Short-term effects of synthetic human parathyroid hormone-(1--34) administration on bone mineral metabolism in osteoporotic patients.
It is indicated that low doses of parathyroid hormone may promote bone formation, whereas higher doses clearly have an adverse effect on the skeleton. Expand
Calcium-47 kinetic measurements of bone turnover compared to bone histomorphometry in osteoporosis: the influence of human parathyroid fragment (hPTH 1-34) therapy.
Nineteen patients with involutional osteoporosis have been studied by means of combined 47 Ca kinetic and calcium balance studies and morphometric analysis of iliac crest bone biopsies taken after double tetracycline labelling, finding a close inverse relationship was found in the untreated patients between trabecular resorption surfaces (RS%) and calcium Balance. Expand
Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor.
The anti-CaSR antibody-mediated inhibition of CaSR-stimulated ERK1/2 activity, but not of inositol-1-phosphate accumulation, suggests that ERK 1/2 may mediate, at least in part, the regulation of PTH secretion and urinary calcium excretion by the CaSR. Expand
Quantitative digital radiography versus dual photon absorptiometry of the lumbar spine.
Quantitative digital radiography's image resolution was superior to that of DPA, enabling it to measure more bones, and the elimination of 153Gd source changes and Nuclear Regulatory Commission licensing requirements indicate that quantitativedigital radiography is the superior method for spinal BMD measurements. Expand