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Proposal of a 2-Tier Histologic Grading System for Canine Cutaneous Mast Cell Tumors to More Accurately Predict Biological Behavior
According to the novel grading system, high-grade MCTs were significantly associated with shorter time to metastasis or new tumor development, and with shorter survival time. Expand
Canine cutaneous mast cell tumors: A combined clinical and pathologic approach to diagnosis, prognosis, and treatment selection.
This manuscript reviews the current state of diagnostics and prognostication of canine cutaneous mast cell tumors, and suggests a combined approach based on clinical and pathologic assessment for decision making regarding treatment choices. Expand
Accurately Predict Biological Behavior Proposal of a 2-Tier Histologic Grading System for Canine Cutaneous Mast Cell Tumors to More
Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinaryExpand
Recommended Guidelines for Submission, Trimming, Margin Evaluation, and Reporting of Tumor Biopsy Specimens in Veterinary Surgical Pathology
Questions of technique, analysis, and evaluation should be put through formal scrutiny in rigorous clinical studies in the near future so that more definitive guidelines can be derived. Expand
Immunohistochemical Diagnosis of Canine Oral Amelanotic Melanocytic Neoplasms
A cost-effective and efficient immunodiagnostic cocktail containing antibodies against PNL2, Melan-A, TRP-1, andTRP-2 was created that had 100% specificity and 93.9% sensitivity in identifying canine oral amelanotic melanocytic neoplasms. Expand
Equine Herpesvirus 2-Associated Granulomatous Dermatitis in a Horse
A case of recurrent equine granulomatous skin disease characterized by intranuclear viral inclusions within macrophages and giant cells and Sequence results of the polymerase chain reaction product were consistent with equine herpesvirus 2, adding another possible etiology to the list of differentials. Expand
Outbreak of Neonatal Diarrhea in Farmed Mink Kits (Mustella vison) Associated With Enterotoxigenic Staphylococcus delphini
The authors postulate that the observed hypersecretory diarrhea in these mink kits was the result of colonization of the small intestine by S delphini and subsequent production of enterotoxin. Expand
Surgical Amputation of a Digit and Vacuum-Assisted-Closure (V.A.C.) Management in a Case of Osteomyelitis and Wound Care in an Eastern Black Rhinoceros (Diceros bicornis michaeli)
The use of negative-pressure wound therapy appeared to shorten time to resolution of slow-healing wounds in black rhinoceros, and expedited the formation of healthy granulation tissue and overall healing was accelerated. Expand
Differences in Expression of Uroplakin III, Cytokeratin 7, and Cyclooxygenase-2 in Canine Proliferative Urothelial Lesions of the Urinary Bladder
The expression of immunohistochemical markers that have been used in diagnosis and/or prognostication of urothelial tumors in humans was evaluated and compared to the lesion classification and grade as defined by the World Health Organization / International Society of Urologic Pathology consensus system. Expand
Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs
The results, in a canine large animal model, support caution when considering surgical vit rectomy before IVT for retinal gene therapy in patients, as prior vitrectomy appears to significantly reduce transduction efficiency and may predispose the patient to development of vector-induced immune reactions. Expand