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The effect of cadmium on the formation and properties of hydroxyapatite In vitro and its relation to cadmium toxicity in the skeletal system
- N. Blumenthal, V. Cosma, D. Skyler, J. Legeros, M. Walters
- Chemistry, Medicine
- Calcified Tissue International
- 1 April 1995
Cd had an inhibitory effect on HA formation kinetics in all three test systems, which explains the Cd incorporation reported in bone and probably has little effect on bone mineral dissolution. Expand
The pyridoacridine family tree: a useful scheme for designing synthesis and predicting undiscovered natural products.
The pyridoacridine natural products represent a large and growing class and serve here to illustrate the wealth of information that can be extracted by comparing natural products on the basis of… Expand
A simple biomimetic synthesis of styelsamine B.
An extremely rapid, low cost, and environmentally friendly entry into the pyridoacridine family of alkaloids has been devised, as demonstrated here by the first total synthesis of styelsamine B (3)… Expand
The activated core approach to combinatorial chemistry: A selection of new core molecules
Abstract Four new activated core molecules suitable for use in solution-phase combinatorial organic chemistry have been prepared. These molecules represent an attempt to further explore shape-space… Expand
Synthesis and screening of small molecule libraries active in binding to DNA.
- G. Shipps, K. Pryor, J. Xian, D. Skyler, E. H. Davidson, J. Rebek
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 28 October 1997
Five synthetic combinatorial libraries of 2,080 components each were screened as mixtures for inhibition of DNA binding to two transcription factors and the efficient deconvolution through sublibrary synthesis augurs well for the use of large mixtures of small, nonpeptide molecules in biological screens. Expand
The Activated Core Approach to Combinatorial Chemistry: A Selection of New Core Molecules
Synthesis and screening of small molecule libraries active in binding to DNA (diversityycombinatorial chemistryyureasygel-shift assayyDNA binding)
Five synthetic combinatorial libraries of 2,080 components each were screened as mixtures for inhibi- tion of DNA binding to two transcription factors, leading to the identification of two compounds active at a 5- to 10-mM concentration level. Expand
High-Performance, Low-Temperature-Operating, Long-Lifetime Aerospace Lubricants
II matrix cracking. Failure initiation isdetermined using a failure criterion,and the evolution of these ISVs is con-trolled by a set of traction-separationlaws. The traction separation laws… Expand
NOVEL PLASTICIZER FOR IM COMPLIANT SOLID PROPELLANTS
Abstract : NITROFURAZAN PLASTICIZERS (NF): Nitrofurazan family offers promise as high energy, good thermal behavior, high density and low sensitivity plasticizers. * NF core: heterocyclic ring with… Expand
A Simple Biomimetic Synthesis of Styelsamine B (III).