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Drug‐Associated Hospital Admissions in Older Medical Patients
TLDR
Females had significantly more adverse drug reactions, although sex was not a predictor for overall DRAPE risk, and age was not correlated with the risk of a DRAPE.
Clinical Pharmacokinetics of Amantadine Hydrochloride
TLDR
Dose schedules have been suggested for individuals in whom amantadine kinetics are different from healthy subjects, however, these schedules are controversial in their choice of target concentrations and in being untested as to predictive value.
Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza
TLDR
Oseltamivir was well absorbed enterically in critically ill patients admitted to the ICU with suspected or confirmed pandemic (H1N1) influenza and adjustment of the dosage in patients with renal dysfunction requiring continuous renal replacement therapy is appropriate; adjustment for obesity does not appear to be necessary.
Pill Count, Self-Report, and Pharmacy Claims Data to Measure Medication Adherence in the Elderly
TLDR
The pill count technique used in this study of elderly clients using chronic, repeat medications appeared to underestimate medication adherence, among other limitations of pill count, self-report, and a province-wide prescription claims database in estimating medication adherence are presented.
Pharmacokinetics and Pharmacodynamics of Meropenem in Febrile Neutropenic Patients with Bacteremia
TLDR
Based on the first published report of a relationship between a pharmacodynamic index and clinical outcome in a febrile neutropenic population, dosing with intravenous meropenem 500 mg every 6 hours is predicted to be comparable to the currently recommended 1 g every 8 hours for serious infections.
Antibiotic‐Heparin Lock: In Vitro Antibiotic Stability Combined with Heparin in a Central Venous Catheter
TLDR
It is concluded that the concentrations of vancomycin, ceftazidime, cefazolin, or gentamicin used in this study should be sufficient for an antibiotic‐heparin lock to decrease the frequency of infections associated with CVCs.
Pharmacokinetic aspects of theophylline in premature newborns.
To characterize further the pharmacokinetics of theophylline in premature infants, its concentraion in blood was measured by high-pressure liquid chromatography after intravenous infusion given to
Ethanol 'dose-dependent' elimination: Michaelis-Menten v classical kinetic analysis.
1 To compare classical linear regression techniques and a Michaelis-Menten elimination model eight normal human volunteers each received three intravenous doses (0.375, 0.5, and 0.75 g/kg) of ethanol
Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis.
TLDR
This meta-analysis suggests that 5 days of short-acting antibiotic use is effective treatment for uncomplicated acute otitis media in children.
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