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Increased basal and thrombin-induced free calcium in platelets of essential hypertensive patients.
It is suggested that, in essential hypertension, there is not only increased platelet resting [Ca2+]i but also an increase in agonist-mediated calcium influx, which appears to indicate a cell membrane abnormality in the platelets of subjects with essential hypertension.
Verapamil inhibits platelet aggregation by a calcium-independent mechanism.
- G. Bonadonna, C. Lechi, P. Corradini, D. Sinigaglia, P. De Togni, G. Miroslawa
- Biology, MedicineThrombosis and haemostasis
- 15 December 1986
It is deduced that a calcium-independent mechanism plays a role in verapamil-induced inhibition of platelet aggregation and postulate that this mechanism may operate via a protein-kinase C pathway.
Platelet intracellular calcium in patients with Duchenne muscular dystrophy.
Increased platelet aggregation and intracellular calcium in hypertensive patients: effects of cyclo-oxygenase blockade.
- C. Lechi, E. Arosio, A. Lechi
- Medicine, BiologyJournal of hypertension. Supplement : official…
- 1 December 1989
Thromboxane system activity is increased in the platelets of hypertensive patients, andUrinary excretion of 2,3-dinor-throm boxane B2, the main metabolite of platelet thromboxanes A2, was slightly, but not significantly increased, in the hypertensive Patients.
Intracellular free Ca2+ in platelets of essential hypertensive patients. Lack of correlation with clinical and laboratory data.
- C. Lechi, D. Sinigaglia, M. Corsato, G. Covi, E. Arosio, A. Lechi
- Medicine, BiologyJournal of human hypertension
- 1 June 1988
Data appear to support the hypothesis that increased platelet [Ca2+]i in hypertensive patients is more likely to be related to a primary cellular abnormality than to activation by extrinsic humoral or vascular factors.
Antimicrobial Agents of Microbial Origin : Nisin
- D. Sinigaglia
- 2 December 2010
Platelet intracellular free Ca2+ after incubation with plasma from hypertensive patients.
Findings are not consistent with the hypothesis that the increase in intracellular free calcium observed in platelets of hypertensive patients may be due to a plasma ouabain-like factor.
[Marrow homografts in experimental fractures].
[Multiple and temporary percutaneous nailing in fractures of the femur neck].
- D. Sinigaglia
- MedicineMinerva ortopedica
- 1 December 1956