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Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)
TLDR
The results suggest a direct role for O-linked glycosylation by OGT in PcG-mediated epigenetic gene silencing, which is important in developmental regulation, stem cell maintenance, genomic imprinting, and cancer. Expand
The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.
TLDR
It is shown that Asx is required in the central nervous system to regulate Ultrabithorax and differences in target site recognition may account for some of the differences in Asx phenotypes relative to other members of the Polycomb group. Expand
The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals.
TLDR
The occurrence of E(Pc) across such divergent species is unusual for both PcG proteins and for suppressors of position-effect variegation, and suggests that E(pc) has an important role in the regulation of chromatin structure in eukaryotes. Expand
dSet1 Is the Main H3K4 Di- and Tri-Methyltransferase Throughout Drosophila Development
TLDR
The results suggest that dSet1 is responsible for the bulk of H3K4 di- and trimethylation throughout Drosophila development, thus providing a model system for better understanding the requirements for and functions of these modifications in metazoans. Expand
The light gene of Drosophila melanogaster encodes a homologue of VPS41, a yeast gene involved in cellular-protein trafficking.
TLDR
The lt gene appears to be expressed at relatively high levels in all stages and tissues examined, and shows strong homology to VPS41, a gene involved in cellular-protein trafficking in yeast and higher eukaryotes, which point to a role for lt in transport processes. Expand
Genes which suppress position-effect variegation in Drosophila melanogaster are clustered
TLDR
The effects of the suppressors in males appears to be highly dependent upon the presence of the Y chromosome, and examination of the Su(var) mutants at different developmental temperatures indicated that at least one of them is temperature-sensitive. Expand
Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.
TLDR
It is shown that mutations in E(Pc), an unusual member of the PcG, suppress PEV of four variegating rearrangements: In(l)wm4, B(SV), T(2;3)Sb(V) and In(2R)bw(VDe2), which supports the conclusion that there are fewer similarities between P cG genes and modifiers of PEV than previously supposed. Expand
A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster.
TLDR
Results are consistent with the hypothesis that two of these Su(var) genes encode structural components of heterochromatin, and it is reported that two previously isolated mutants located in 31E and 31F-32A act as recessive suppressors of PEV. Expand
The polyhomeotic locus of Drosophila melanogaster is transcriptionally and post-transcriptionally regulated during embryogenesis
TLDR
Results show that the ph locus undergoes complex developmental regulation, and suggest that Polycomb group regulation may be more dynamic than anticipated. Expand
A Genetic and Molecular Characterization of Two Proximal Heterochromatic Genes on Chromosome 3 of Drosophila melanogaster
TLDR
The cloning and characterization of two proximal heterochromatic genes in D. melanogaster are reported, one of which is uncharacteristically small, is highly expressed, and encodes an essential ribosomal protein and the other is very large, likely to be a nonessential gene. Expand
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