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- Publications
- Influence
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy
- R. Heaton, D. Clifford, +23 authors I. Grant
- Medicine
- Neurology
- 7 December 2010
Objectives: This is a cross-sectional, observational study to determine the frequency and associated features of HIV-associated neurocognitive disorders (HAND) in a large, diverse sample of infected… Expand
HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
- R. Heaton, D. Franklin, +24 authors I. Grant
- Medicine
- Journal of NeuroVirology
- 21 December 2010
Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be… Expand
The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
- C. Baigent, M. Landray, +47 authors R. Collins
- Medicine
- The Lancet
- 9 June 2011
Summary Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney… Expand
Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia.
- J. Burger, A. Tedeschi, +31 authors T. Kipps
- Medicine
- The New England journal of medicine
- 16 December 2015
BACKGROUND
Chronic lymphocytic leukemia (CLL) primarily affects older persons who often have coexisting conditions in addition to disease-related immunosuppression and myelosuppression. We conducted… Expand
Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases
- D. Clifford, A. DeLuca, D. Simpson, G. Arendt, Avindra Nath
- Medicine
- The Lancet Neurology
- 1 April 2010
BACKGROUND
Treatment of multiple sclerosis with natalizumab is complicated by rare occurrence of progressive multifocal leukoencephalopathy (PML). Between July, 2006, and November, 2009, there were… Expand
Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network
- J. Claassen, A. M. D. Meel-van den Abeelen, D. Simpson, R. B. Panerai
- Psychology, Medicine
- Journal of cerebral blood flow and metabolism…
- 18 January 2016
Cerebral autoregulation is the intrinsic ability of the brain to maintain adequate cerebral perfusion in the presence of blood pressure changes. A large number of methods to assess the quality of… Expand
Efavirenz concentrations in CSF exceed IC50 for wild-type HIV.
- B. Best, P. Koopmans, +11 authors I. Grant
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
- 1 February 2011
OBJECTIVES
HIV-associated neurocognitive disorders remain common despite use of potent antiretroviral therapy (ART). Ongoing viral replication due to poor distribution of antivirals into the CNS may… Expand
HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy
- D. Clifford, C. Yiannoutsos, +9 authors N. Hyslop
- Medicine
- Neurology
- 1 February 1999
Article abstract Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of… Expand
Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline
- I. Grant, D. Franklin, +19 authors R. Heaton
- Medicine
- Neurology
- 10 June 2014
Objective: While HIV-associated neurocognitive disorders (HAND) remain prevalent despite combination antiretroviral therapy (CART), the clinical relevance of asymptomatic neurocognitive impairment… Expand
Lamotrigine for HIV-associated painful sensory neuropathies
- D. Simpson, J. McArthur, +6 authors A. Hammer
- Medicine
- Neurology
- 13 May 2003
Objective: To evaluate the efficacy and tolerability of lamotrigine (LTG) for the treatment of pain in HIV-associated sensory neuropathies. Methods: In a randomized, double-blind study, patients with… Expand