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Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality.
While the "socio-genomes" of ants and the honeybee are broadly characterized by a pervasive pattern of divergence in gene composition and regulation, they preserve lineage-specific regulatory features linked to eusociality, it is proposed that changes in gene regulation played a key role in the origins of insect eussociality.
DNA methylation in social insects: how epigenetics can control behavior and longevity.
- Hua Yan, R. Bonasio, D. Simola, J. Liebig, S. Berger, D. Reinberg
- Biology, MedicineAnnual review of entomology
- 7 January 2015
Recent advances in DNA methylation research are summarized and its significance in understanding of the epigenetic underpinnings of behavior and longevity is discussed.
Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
Findings reveal the epigenome as a likely substrate underlying caste-based division of labor in eusocial insects as well as the conserved role of CBP in learning and memory in both invertebrates and mammals.
Mechanisms and Dynamics of Orphan Gene Emergence in Insect Genomes
- Lothar Wissler, J. Gadau, D. Simola, M. Helmkampf, E. Bornberg-Bauer
- Biology, MedicineGenome biology and evolution
- 24 January 2013
The results indicate that the genetic mechanisms creating orphan genes—such as gene duplication, frame-shift fixation, creation of overlapping genes, horizontal gene transfer, and exaptation of transposable elements—act at different rates in insects, primates, and plants.
Eusocial insects as emerging models for behavioural epigenetics
- Hua Yan, D. Simola, R. Bonasio, J. Liebig, S. Berger, D. Reinberg
- Biology, MedicineNature Reviews Genetics
- 1 October 2014
This Review summarizes recent studies in the epigenetics of social behaviour and offers perspectives on emerging trends and prospects for establishing genetic tools in eusocial insects.
MLL1 is essential for the senescence-associated secretory phenotype.
- Brian C. Capell, Adam M. Drake, +11 authors S. Berger
- Biology, MedicineGenes & development
- 1 February 2016
Data demonstrate that MLL1 inhibition may be a powerful and effective strategy for inducing cancerous growth arrest through the direct epigenetic regulation of proliferation-promoting genes and the avoidance of deleterious OIS- or TIS-related tumor secretomes, which can promote both drug resistance and tumor progression.
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations
In insights pertaining to the identification of bacterial targets in the lung and biomarkers to classify COPD subtypes and to determine appropriate treatments for the patient, the stability of the lung microbiome over time was more likely to be decreased in exacerbations and within individuals with higher exacerbation frequencies.
A chromatin link to caste identity in the carpenter ant Camponotus floridanus.
It is proposed that epigenetic mechanisms that modify chromatin structure may help orchestrate the generation and maintenance of polyphenic caste morphology and social behavior in ants.
The genomic impact of 100 million years of social evolution in seven ant species.
- J. Gadau, M. Helmkampf, +6 authors Christopher D. Smith
- Biology, MedicineTrends in genetics : TIG
Comparing the ant genomes with those of the honeybee, a lineage that evolved eusociality independently from ants, and solitary insects suggests that there are significant differences in key aspects of genome organization between social and solitary animals, as well as among ant species.
Heterochronic evolution reveals modular timing changes in budding yeast transcriptomes
- D. Simola, Chantal A. Francis, P. Sniegowski, Junhyong Kim
- Biology, MedicineGenome Biology
- 22 October 2010
It is proposed that transcriptome evolution may generally entail changes in timing (heterochrony) rather than changes in levels (heterometry) of expression, and that genome-wide gene regulation may utilize a general architecture comprised of multiple semi-autonomous event timelines, whose superposition could produce combinatorial complexity in timing control patterns.