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How a Circadian Clock Adapts to Seasonal Decreases in Temperature and Day Length
We show that a thermosensitive splicing event in the 3' untranslated region of the mRNA from the period (per) gene plays an important role in how a circadian clock in Drosophila adapts to seasonallyExpand
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Circadian Regulation of a Drosophila Homolog of the Mammalian Clock Gene: PER and TIM Function as Positive Regulators
ABSTRACT The Clock gene plays an essential role in the manifestation of circadian rhythms (≅24 h) in mice and is a member of the basic helix-loop-helix (bHLH) PER-ARNT-SIM (PAS) superfamily ofExpand
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Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding.
The LytTR domain is a DNA-binding motif found within the AlgR/AgrA/LytR family of transcription factors that regulate virulence factor and toxin gene expression in pathogenic bacteria. ThisExpand
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Integrative analysis of chromatin states in Arabidopsis identified potential regulatory mechanisms for natural antisense transcript production.
Genome-wide analyses of epigenomic and transcriptomic profiles provide extensive resources for discovering epigenetic regulatory mechanisms. However, the construction of functionally relevantExpand
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Differential Effects of Light and Heat on theDrosophila Circadian Clock Proteins PER and TIM
ABSTRACT Circadian (≅24-h) rhythms are governed by endogenous biochemical oscillators (clocks) that in a wide variety of organisms can be phase shifted (i.e., delayed or advanced) by brief exposureExpand
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Structural basis for RNA duplex recognition and unwinding by the DEAD-box helicase Mss116p
DEAD-box proteins are the largest family of nucleic acid helicases, and are crucial to RNA metabolism throughout all domains of life. They contain a conserved ‘helicase core’ of two RecA-like domainsExpand
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Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase–Cas1 fusion protein
CRISPR-Cas captures invading RNA The CRISPR (clustered regularly interspaced short palindromic repeat) system provides bacteria with an adaptive immune response. DNA captured from viruses andExpand
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Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding.
The AgrA transcription factor regulates the quorum-sensing response in Staphylococcus aureus, controlling the production of hemolysins and other virulence factors. AgrA binds to DNA via itsExpand
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NMR structure of an archaeal homologue of ribonuclease P protein Rpp29.
A protein component of the Archaeoglobus fulgidus RNase P was expressed in Escherichia coli, purified, and structurally characterized using multidimensional NMR methods. The dominant structuralExpand
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Enhanced group II intron retrohoming in magnesium-deficient Escherichia coli via selection of mutations in the ribozyme core
Significance Mobile group II introns are bacterial retrotransposons. They consist of an autocatalytic intron RNA (“ribozyme”) and an intron-encoded reverse transcriptase and were likely ancestors ofExpand
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