D. Shugar

Publications580
h-index48
Citations11,887
Highly Influential Citations229
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The measurement of lysozyme activity and the ultra-violet inactivation of lysozyme.
  • D. Shugar
  • Chemistry, Biology
    Biochimica et biophysica acta
  • 1952
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Selectivity of 4,5,6,7‐tetrabromobenzotriazole, an ATP site‐directed inhibitor of protein kinase CK2 (‘casein kinase‐2’)
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Purine nucleoside phosphorylases: properties, functions, and clinical aspects.
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Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.
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Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus.
TLDR
A large variety of antiherpes compounds was compared for their inhibitory activity against laboratory strains and clinical isolates of herpes simplex virus (HSV) type 1 and type 2, suggesting that phosphorylation by virus-induced TK was required to produce specific inhibition of HSV replication.
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Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.
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Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.
5,6-Dichloro-1-(beta-D-ribofuranosyl)benzimidazole (DiCl-RB) is a powerful inhibitor of casein kinase-2 (CK-2) [Zandomeni, R. et al. (1986) J. Biol. Chem. 261, 3414-3420]. Here a series of 17…
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Halogenated benzimidazoles and benzotriazoles as selective inhibitors of protein kinases CK I and CK II from Saccharomyces cerevisiae and other sources.
TLDR
Two new analogues, tetrahalogeno-2-azabenzimidazoles, are even more potent inhibitors of CK II and much less so of CK I from yeast and animal sources.
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Carbon Monoxide Neurotransmission Activated by CK2 Phosphorylation of Heme Oxygenase-2
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Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.
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