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Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.
- A. Schmidt, N. Endo, S. Rutledge, R. Vogel, D. Shinar, G. Rodan
- Biology, Medicine
- Molecular endocrinology
- 1 October 1992
We have identified a novel member of the steroid hormone receptor superfamily by cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. Sequence analysis predicts a protein of 441 amino… Expand
Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity
Drug-induced nephrotoxicity is a major concern, since many pharmacological compounds are filtered through the kidneys for excretion into urine. To discover biochemical biomarkers useful for early… Expand
Different pattern of alkaline phosphatase, osteopontin, and osteocalcin expression in developing rat bone visualized by in situ hybridization
- M. Weinreb, D. Shinar, G. Rodan
- Biology, Medicine
- Journal of bone and mineral research : the…
- 1 August 1990
Alkaline phosphatase (AP), osteopontin (OP), and osteocalcin (OC) are expressed during osteoblastic differentiation. However, previous studies suggested differences in the timing and possibly the… Expand
Biphasic effects of transforming growth factor-beta on the production of osteoclast-like cells in mouse bone marrow cultures: the role of prostaglandins in the generation of these cells.
Osteoclast-like multinucleated giant cells are induced in bone marrow cultures by 1,25-dihydroxyvitamin D3 and other agents. These cells resemble osteoclasts in their morphology, their ability to… Expand
NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.
- D. Shinar, N. Endo, S. Rutledge, R. Vogel, G. Rodan, A. Schmidt
- Biology, Medicine
- 30 September 1994
NER, a new member of the steroid hormone nuclear receptor (NR)-encoding gene family, was isolated from a human osteosarcoma SAOS/B10 cell line cDNA library. NER codes for a polypeptide of 461 amino… Expand
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor
- J. Kaye, V. Piryatinsky, +16 authors R. Laufer
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 26 September 2016
Significance Laquinimod is an oral drug currently being evaluated for the treatment of relapsing, remitting, and primary progressive multiple sclerosis as well as Huntington’s disease. It is thought… Expand
Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone.
Insulin-like growth factors (IGF-I and IGF-II) are among the most abundant growth factors found in bone. Although their local production has been implicated in growth and development, localization of… Expand
Expression of αv and β3 integrin subunits in rat osteoclasts in situ
Recent findings suggest that the vitronectin receptor, a member of the integrin family, plays an important role in the attachment of osteoclasts to bone matrix. We report here the localization by in… Expand
Comparative Long-Term Preclinical Safety Evaluation of Two Glatiramoid Compounds (Glatiramer Acetate, Copaxone®, and TV-5010, Protiramer) in Rats and Monkeys
- Y. Ramot, M. Rosenstock, E. Klinger, Dizza Bursztyn, A. Nyska, D. Shinar
- Toxicologic pathology
- 1 January 2012
Glatiramer acetate (GA), the active ingredient in Copaxone®, is a complex mixture of polypeptides used for the treatment of relapsing remitting multiple sclerosis. Glatiramoids are related mixtures… Expand
The effect of hemopoietic growth factors on the generation of osteoclast-like cells in mouse bone marrow cultures.
Multinucleated cells containing tartrate-resistant acid phosphatase were produced in mouse bone marrow cultures in response to 1,25-dihydroxyvitamin D3. These cells resemble osteoclasts in their… Expand