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MethyLight: a high-throughput assay to measure DNA methylation.
Cytosine-5 DNA methylation occurs in the context of CpG dinucleotides in vertebrates. Aberrant methylation of CpG islands in human tumors has been shown to cause transcriptional silencing ofExpand
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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
SPONTANEOUS errors in DNA replication have been suggested to play a significant role in neoplastic transformation and to explain the chromosomal alterations seen in cancer cells1. A defectiveExpand
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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Using in vitro gene amplification by the polymerase chain reaction (PCR) and mutation detection by the RNAase A mismatch cleavage method, we have examined c-K-ras genes in human pancreaticExpand
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A Big Bang model of human colorectal tumor growth
What happens in early, still undetectable human malignancies is unknown because direct observations are impractical. Here we present and validate a 'Big Bang' model, whereby tumors grow predominantlyExpand
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Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer
Dissecting Diversity Solid tumors are composed of functionally diverse tumor cells. The prevailing view is that this "intratumoral heterogeneity" arises from the accumulation of mutations duringExpand
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Epstein-Barr virus-associated gastric adenocarcinoma.
The Epstein-Barr virus (EBV) has been detected in certain types of lymphoma and some epithelial neoplasms including nasopharyngeal lymphoepithelioma, and rare lymphoepithelioma-like carcinomasExpand
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Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
Genomic instability at simple repeated sequences (SRS) is a landmark for some sporadic and hereditary cancers of the colon. We have identified several human tumour cell lines with up to 1,000–foldExpand
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Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
Many human cancer susceptibility genes have been successfully mapped by genetic linkage studies1. One that has so far eluded researchers is that for Peutz-Jeghers (P-J) syndrome, a conditionExpand
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The DCC protein and prognosis in colorectal cancer.
BACKGROUND Allelic loss of chromosome 18q predicts a poor outcome in patients with stage II colorectal cancer. Although the specific gene inactivated by this allelic loss has not been elucidated, theExpand
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Investigating stem cells in human colon by using methylation patterns
The stem cells that maintain human colon crypts are poorly characterized. To better determine stem cell numbers and how they divide, epigenetic patterns were used as cell fate markers. MethylationExpand
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